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Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit

Science, 2 March 2007
Vol. 315, Issue 5816, p. 1262-1266
DOI: 10.1126/science.1137450

Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit

  1. Karri P. Lamsa1,
  2. Joost H. Heeroma1,
  3. Peter Somogyi2,
  4. Dmitri A. Rusakov1,
  5. Dimitri M. Kullmann1,*
  1. 1 Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
  2. 2 Anatomical Neuropharmacology Unit, Medical Research Council, Oxford University, Mansfield Road, Oxford OXI 3HT, UK.
  1. * To whom correspondence should be addressed. E-mail: d.kullmann{at}ion.ucl.ac.uk

Abstract

Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is “anti-Hebbian”:Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.

  • Received for publication 13 November 2006.
  • Accepted for publication 1 February 2007.

Citation:

K. P. Lamsa, J. H. Heeroma, P. Somogyi, D. A. Rusakov, and D. M. Kullmann, Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit. Science 315, 1262-1266 (2007).

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