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Deconstructing the Hedgehog Pathway in Development and Disease

Science, 5 October 2007
Vol. 318, Issue 5847, p. 66-68
DOI: 10.1126/science.1147314

Deconstructing the Hedgehog Pathway in Development and Disease

  1. Leni Jacob,
  2. Lawrence Lum*
  1. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  1. * To whom correspondence should be addressed. E-mail: lawrence.lum{at}


The Hedgehog (Hh) family of secreted signaling proteins is a master regulator of cell fate determination in metazoans, contributing to both pattern formation during embryonic development and postembryonic tissue homeostasis. In a universally used mode of action, graded distribution of Hh protein induces differential cell fate in a dose-dependent manner in cells that receive Hh. Though much of this pathway has been elucidated from genetically based studies in model organisms, such as Drosophila and mice, the importance of Hh-mediated signaling in humans is clearly evident from malformations and a broad range of cancers that arise when the pathway is corrupted.


L. Jacob and L. Lum, Deconstructing the Hedgehog Pathway in Development and Disease. Science 318, 66-68 (2007).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882