Error message

No crossref credentials set for sci

Genetic Determinants of Self Identity and Social Recognition in Bacteria

Science, 11 July 2008
Vol. 321, Issue 5886, p. 256-259
DOI: 10.1126/science.1160033

Genetic Determinants of Self Identity and Social Recognition in Bacteria

  1. Karine A. Gibbs1,*,
  2. Mark L. Urbanowski2,*,
  3. E. Peter Greenberg1,
  1. 1 Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
  2. 2 Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  1. To whom correspondence should be addressed. E-mail: epgreen{at}u.washington.edu
  • * These authors contributed equally to this work.

Abstract

The bacterium Proteus mirabilis is capable of movement on solid surfaces by a type of motility called swarming. Boundaries form between swarming colonies of different P. mirabilis strains but not between colonies of a single strain. A fundamental requirement for boundary formation is the ability to discriminate between self and nonself. We have isolated mutants that form boundaries with their parent. The mutations map within a six-gene locus that we term ids for identification of self. Five of the genes in the ids locus are required for recognition of the parent strain as self. Three of the ids genes are interchangeable between strains, and two encode specific molecular identifiers.

    • Received for publication 5 May 2008.
    • Accepted for publication 6 June 2008.

    Citation:

    K. A. Gibbs, M. L. Urbanowski, and E. P. Greenberg, Genetic Determinants of Self Identity and Social Recognition in Bacteria. Science 321, 256-259 (2008).

    Transcriptional Analysis of the MrpJ Network: Modulation of Diverse Virulence-Associated Genes and Direct Regulation of mrp Fimbrial and flhDC Flagellar Operons in Proteus mirabilis
    N. J. Bode, I. Debnath, L. Kuan, A. Schulfer, M. Ty, and M. M. Pearson
    Infect. Immun. 83, 2542-2556 (1 June 2015)

    Characterization of 17 chaperone-usher fimbriae encoded by Proteus mirabilis reveals strong conservation
    L. Kuan, J. N. Schaffer, C. D. Zouzias, and M. M. Pearson
    J Med Microbiol 63, 911-922 (1 July 2014)

    The Complete Genome Sequence of Proteus mirabilis Strain BB2000 Reveals Differences from the P. mirabilis Reference Strain
    N. L. Sullivan, A. N. Septer, A. T. Fields, L. M. Wenren, and K. A. Gibbs
    Genome Announc 1, e00024-13-e00024-13 (31 October 2013)

    Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export
    L. M. Wenren, N. L. Sullivan, L. Cardarelli, A. N. Septer, and K. A. Gibbs
    mBio 4, e00374-13-e00374-13 (23 July 2013)

    Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae
    S. Bruckner, and H.-U. Mosch
    FEMS Microbiol Rev 36, 25-58 (1 January 2012)

    Mutually facilitated dispersal between the nonmotile fungus Aspergillus fumigatus and the swarming bacterium Paenibacillus vortex
    C. J. Ingham, O. Kalisman, A. Finkelshtein, and E. Ben-Jacob
    Proc. Natl. Acad. Sci. USA 108, 19731-19736 (6 December 2011)

    The ubiquity of consciousness: The ubiquity of consciousness, cognition and intelligence in life
    A. J. Trewavas, and F. Baluska
    EMBO Rep. 12, 1221-1225 (1 December 2011)

    Identity Gene Expression in Proteus mirabilis
    K. A. Gibbs, L. M. Wenren, and E. P. Greenberg
    J. Bacteriol. 193, 3286-3292 (1 July 2011)

    Genomic analysis of the type VI secretion systems in Pseudomonas spp.: novel clusters and putative effectors uncovered
    M. Barret, F. Egan, E. Fargier, J. P. Morrissey, and F. O'Gara
    Microbiology 157, 1726-1739 (1 June 2011)

    Surviving Bacterial Sibling Rivalry: Inducible and Reversible Phenotypic Switching in Paenibacillus dendritiformis
    A. Be'er, E.- L. Florin, C. R. Fisher, H. L. Swinney, and S. M. Payne
    mBio 2, e00069-11-e00069-11 (31 May 2011)

    Natural variation in developmental life-history traits of the bacterium Myxococcus xanthus
    S. A. Kraemer, M. A. Toups, and G. J. Velicer
    FEMS Microbiol Ecol 73, 226-233 (1 August 2010)

    A global network of coexisting microbes from environmental and whole-genome sequence data
    S. Chaffron, H. Rehrauer, J. Pernthaler, and C. von Mering
    Genome Res 20, 947-959 (1 July 2010)

    Lethal protein produced in response to competition between sibling bacterial colonies
    A. Be'er, G. Ariel, O. Kalisman, Y. Helman, A. Sirota-Madi, H. P. Zhang, E.- L. Florin, S. M. Payne, E. Ben-Jacob, H. L. Swinney et al.
    Proc. Natl. Acad. Sci. USA 107, 6258-6263 (6 April 2010)

    Generational coexistence and ancestor's inhibition in bacterial populations
    F. Baquero, and M. Lemonnier
    FEMS Microbiol Rev 33, 958-967 (1 September 2009)

    Growing Bacillus subtilis tendrils sense and avoid each other
    B. L. James, J. Kret, J. E. Patrick, D. B. Kearns, and R. Fall
    FEMS Microbiol Lett 298, 12-19 (1 September 2009)

    The Dienes Phenomenon: Competition and Territoriality in Swarming Proteus mirabilis
    A. E. Budding, C. J. Ingham, W. Bitter, C. M. Vandenbroucke-Grauls, and P. M. Schneeberger
    J. Bacteriol. 191, 3892-3900 (15 June 2009)

    Getting in Touch with Your Friends
    C. J. Marx, C. J. Ingham, W. Bitter, C. M. Vandenbroucke-Grauls, and P. M. Schneeberger
    Science 324, 1150-1151 (29 May 2009)

    Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882