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Feedback Loops Shape Cellular Signals in Space and Time

Science, 17 October 2008
Vol. 322, Issue 5900, p. 390-395
DOI: 10.1126/science.1160617

Feedback Loops Shape Cellular Signals in Space and Time

  1. Onn Brandman1,
  2. Tobias Meyer2
  1. 1 Department of Cellular and Molecular Pharmacology, University of California-San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA. E-mail: Onn.Brandman{at}ucsf.edu
  2. 2 Department of Chemical and Systems Biology, 318 Campus Drive, Clark Building W200, Stanford University Medical Center, Stanford, CA 94305–5174, USA. E-mail: tobias1{at}stanford.edu

Abstract

Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.

Citation:

O. Brandman and T. Meyer, Feedback Loops Shape Cellular Signals in Space and Time. Science 322, 390-395 (2008).

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