Error message

No crossref credentials set for sci

Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

Science, 6 February 2009
Vol. 323, Issue 5915, p. 800-802
DOI: 10.1126/science.1166102

Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

  1. Fiona McNab1,
  2. Andrea Varrone2,
  3. Lars Farde2,3,
  4. Aurelija Jucaite2,3,
  5. Paulina Bystritsky1,
  6. Hans Forssberg1,
  7. Torkel Klingberg1,*
  1. 1 Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden.
  2. 2 Department of Clinical Neuroscience, Psychiatry Section, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden.
  3. 3 AstraZeneca Research and Development, Södertälje, Sweden.
  1. * To whom correspondence should be addressed. E-mail: torkel.klingberg{at}ki.se

Abstract

Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

  • Received for publication 18 September 2008.
  • Accepted for publication 10 December 2008.

Citation:

F. McNab, A. Varrone, L. Farde, A. Jucaite, P. Bystritsky, H. Forssberg, and T. Klingberg, Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training. Science 323, 800-802 (2009).

ADHD Symptomatology and Risky Health, Driving, and Financial Behaviors in College: The Mediating Role of Sensation Seeking and Effortful Control
P. A. Graziano, A. Reid, J. Slavec, A. Paneto, J. P. McNamara, and G. R. Geffken
J Atten Disord 19, 179-190 (1 March 2015)

Therapeutic Opportunities for Self-Control Repair in Addiction and Related Disorders: Change and the Limits of Change in Trans-Disease Processes
W. K. Bickel, A. J. Quisenberry, L. Moody, and A. G. Wilson
Clinical Psychological Science 3, 140-153 (1 January 2015)

Resting-State fMRI: A Window into Human Brain Plasticity
B. Guerra-Carrillo, A. P. Mackey, and S. A. Bunge
Neuroscientist 20, 522-533 (1 October 2014)

Interactive Effects of the COMT Gene and Training on Individual Differences in Supervisory Control of Unmanned Vehicles
R. Parasuraman, B. Kidwell, R. Olmstead, M.-K. Lin, R. Jankord, and P. Greenwood
Human Factors: The Journal of the Human Factors and Ergonomics Society 56, 760-771 (1 June 2014)

Visual perception from the perspective of a representational, non-reductionistic, level-dependent account of perception and conscious awareness
M. Overgaard, and J. Mogensen
Phil Trans R Soc B 369, 20130209-20130209 (5 May 2014)

Cogmed Working Memory Training Product Review
J. D. Roche, and B. D. Johnson
J Atten Disord 18, 379-384 (1 May 2014)

Effectiveness of Computerized Working Memory Training Program in Chinese Community Settings for Children With Poor Working Memory
A. S. Y. Wong, M. Y. Q. He, and R. W. S. Chan
J Atten Disord 18, 318-330 (1 May 2014)

Structural Maturation and Brain Activity Predict Future Working Memory Capacity during Childhood Development
H. Ullman, R. Almeida, and T. Klingberg
J. Neurosci. 34, 1592-1598 (29 January 2014)

Optimizing Working Memory with Heterogeneity of Recurrent Cortical Excitation
Z. P. Kilpatrick, B. Ermentrout, and B. Doiron
J. Neurosci. 33, 18999-19011 (27 November 2013)

Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training
C. Wass, A. Pizzo, B. Sauce, Y. Kawasumi, T. Sturzoiu, F. Ree, T. Otto, and L. D. Matzel
Learn. Mem. 20, 617-627 (15 October 2013)

Frontal theta and beta synchronizations for monetary reward increase visual working memory capacity
M. Kawasaki, and Y. Yamaguchi
Soc Cogn Affect Neurosci 8, 523-530 (1 June 2013)

Psychostimulant and Sensory Stimulation Interventions That Target the Reading and Math Deficits of Students With ADHD
S. S. Zentall, K. Tom-Wright, and J. Lee
J Atten Disord 17, 308-329 (1 May 2013)

Nocturnal sleep enhances working memory training in Parkinson's disease but not Lewy body dementia
M. K. Scullin, L. M. Trotti, A. G. Wilson, S. A. Greer, and D. L. Bliwise
Brain 135, 2789-2797 (1 September 2012)

Social-emotional Functioning of Children and Adolescents With Neurofibromatosis Type 1 and Plexiform Neurofibromas: Relationships With Cognitive, Disease, and Environmental Variables
S. Martin, P. Wolters, A. Baldwin, A. Gillespie, E. Dombi, K. Walker, and B. Widemann
J Pediatr Psychol 37, 713-724 (1 August 2012)

Triadic (ecological, neural, cognitive) niche construction: a scenario of human brain evolution extrapolating tool use and language from the control of reaching actions
A. Iriki, and M. Taoka
Phil Trans R Soc B 367, 10-23 (12 January 2012)

Changes in Prefrontal Neuronal Activity after Learning to Perform a Spatial Working Memory Task
X.-L. Qi, T. Meyer, T. R. Stanford, and C. Constantinidis
Cereb Cortex 21, 2722-2732 (1 December 2011)

Domain-specific treatment effects in children with language and/or working memory impairments: A pilot study
S. E. Wener, and L. M. Archibald
Child Language Teaching and Therapy 27, 313-330 (1 October 2011)

Dopamine D1 Receptor Associations within and between Dopaminergic Pathways in Younger and Elderly Adults: Links to Cognitive Performance
A. Rieckmann, S. Karlsson, P. Karlsson, Y. Brehmer, H. Fischer, L. Farde, L. Nyberg, and L. Backman
Cereb Cortex 21, 2023-2032 (1 September 2011)

Effects of Training of Processing Speed on Neural Systems
H. Takeuchi, Y. Taki, H. Hashizume, Y. Sassa, T. Nagase, R. Nouchi, and R. Kawashima
J. Neurosci. 31, 12139-12148 (24 August 2011)

Effects of Working-Memory Training on Striatal Dopamine Release
L. Backman, L. Nyberg, A. Soveri, J. Johansson, M. Andersson, E. Dahlin, A. S. Neely, J. Virta, M. Laine, J. O. Rinne et al.
Science 333, 718-718 (5 August 2011)

Short- and long-term benefits of cognitive training
S. M. Jaeggi, M. Buschkuehl, J. Jonides, and P. Shah
Proc. Natl. Acad. Sci. USA 108, 10081-10086 (21 June 2011)

Harnessing neuroplasticity for clinical applications
S. C. Cramer, M. Sur, B. H. Dobkin, C. O'Brien, T. D. Sanger, J. Q. Trojanowski, J. M. Rumsey, R. Hicks, J. Cameron, D. Chen et al.
Brain 134, 1591-1609 (1 June 2011)

Working memory task performance and chunking in early Alzheimer's disease
J. Huntley, D. Bor, A. Hampshire, A. Owen, and R. Howard
Br. J. Psychiatry 198, 398-403 (1 May 2011)

Dopamine D1 Receptors and Nonlinear Probability Weighting in Risky Choice
H. Takahashi, H. Matsui, C. Camerer, H. Takano, F. Kodaka, T. Ideno, S. Okubo, K. Takemura, R. Arakawa, Y. Eguchi et al.
J. Neurosci. 30, 16567-16572 (8 December 2010)

Mistreating Psychology in the Decades of the Brain
G. A. Miller, H. Matsui, C. Camerer, H. Takano, F. Kodaka, T. Ideno, S. Okubo, K. Takemura, R. Arakawa, Y. Eguchi et al.
Perspectives on Psychological Science 5, 716-743 (1 November 2010)

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human
H. Takahashi, H. Takano, F. Kodaka, R. Arakawa, M. Yamada, T. Otsuka, Y. Hirano, H. Kikyo, Y. Okubo, M. Kato et al.
J. Neurosci. 30, 3043-3047 (24 February 2010)

Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val158met in Healthy Young Adults
B. Liu, M. Song, J. Li, Y. Liu, K. Li, C. Yu, and T. Jiang
J. Neurosci. 30, 64-69 (6 January 2010)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882