Error message

No crossref credentials set for sci

Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex

Science, 26 November 2010
Vol. 330, Issue 6008, p. 1238-1240
DOI: 10.1126/science.1195320

Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex

  1. Hirofumi Morishita1,
  2. Julie M. Miwa2,3,
  3. Nathaniel Heintz3,
  4. Takao K. Hensch1,4,*
  1. 1FM Kirby Neurobiology Center, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
  3. 3Howard Hughes Medical Institute Laboratory of Molecular Biology, Rockefeller University, New York, NY 10065, USA.
  4. 4Center for Brain Science, Department of Molecular Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.
  1. *To whom correspondence should be addressed. E-mail: takao.hensch{at}childrens.harvard.edu

Abstract

Experience-dependent brain plasticity typically declines after an early critical period during which circuits are established. Loss of plasticity with closure of the critical period limits improvement of function in adulthood, but the mechanisms that change the brain’s plasticity remain poorly understood. Here, we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life. Removal of this molecular brake enhanced nicotinic acetylcholine receptor signaling. Lynx1 expression thus maintains stability of mature cortical networks in the presence of cholinergic innervation. The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target.

  • Received for publication 19 July 2010.
  • Accepted for publication 28 September 2010.

Citation:

H. Morishita, J. M. Miwa, N. Heintz, and T. K. Hensch, Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex. Science 330, 1238-1240 (2010).

Ly6h Regulates Trafficking of Alpha7 Nicotinic Acetylcholine Receptors and Nicotine-Induced Potentiation of Glutamatergic Signaling
C. A. Puddifoot, M. Wu, R.-J. Sung, and W. J. Joiner
J. Neurosci. 35, 3420-3430 (25 February 2015)

Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate
S. Miyata, and H. Kitagawa
J Biochem 157, 13-22 (1 January 2015)

Experience-dependent regulation of presynaptic NMDARs enhances neurotransmitter release at neocortical synapses
J. Urban-Ciecko, J. A. Wen, P. K. Parekh, and A. L. Barth
Learn. Mem. 22, 47-55 (1 January 2015)

Lynx1 Shifts {alpha}4{beta}2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum
W. A. Nichols, B. J. Henderson, C. Yu, R. L. Parker, C. I. Richards, H. A. Lester, and J. M. Miwa
J Biol Chem 289, 31423-31432 (7 November 2014)

Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia
D. N. Bochner, R. W. Sapp, J. D. Adelson, S. Zhang, H. Lee, M. Djurisic, J. Syken, Y. Dan, and C. J. Shatz
Sci Transl Med 6, 258ra140-258ra140 (15 October 2014)

Developmental Sculpting of Intracortical Circuits by MHC Class I H2-Db and H2-Kb
J. D. Adelson, R. W. Sapp, B. K. Brott, H. Lee, K. Miyamichi, L. Luo, S. Cheng, M. Djurisic, and C. J. Shatz
Cereb Cortex 0, bhu243v1-bhu243 (14 October 2014)

Plasticity of Binocularity and Visual Acuity Are Differentially Limited by Nogo Receptor
C.-E. Stephany, L. L. H. Chan, S. N. Parivash, H. M. Dorton, M. Piechowicz, S. Qiu, and A. W. McGee
J. Neurosci. 34, 11631-11640 (27 August 2014)

Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity
F. Greifzu, J. Pielecka-Fortuna, E. Kalogeraki, K. Krempler, P. D. Favaro, O. M. Schluter, and S. Lowel
Proc. Natl. Acad. Sci. USA 111, 1150-1155 (21 January 2014)

Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
A. Sale, N. Berardi, and L. Maffei
Physiol. Rev. 94, 189-234 (1 January 2014)

Visual Acuity Development and Plasticity in the Absence of Sensory Experience
E. Kang, S. Durand, J. J. LeBlanc, T. K. Hensch, C. Chen, and M. Fagiolini
J. Neurosci. 33, 17789-17796 (6 November 2013)

Refining Cortical Representation of Sound Azimuths by Auditory Discrimination Training
Y. Zhang, Y. Zhao, X. Zhu, X. Sun, and X. Zhou
J. Neurosci. 33, 9693-9698 (5 June 2013)

Water-soluble LYNX1 Residues Important for Interaction with Muscle-type and/or Neuronal Nicotinic Receptors
E. N. Lyukmanova, M. A. Shulepko, S. L. Buldakova, I. E. Kasheverov, Z. O. Shenkarev, R. V. Reshetnikov, S. Y. Filkin, D. S. Kudryavtsev, L. O. Ojomoko, E. V. Kryukova et al.
J Biol Chem 288, 15888-15899 (31 May 2013)

Visual experience and subsequent sleep induce sequential plastic changes in putative inhibitory and excitatory cortical neurons
S. J. Aton, C. Broussard, M. Dumoulin, J. Seibt, A. Watson, T. Coleman, and M. G. Frank
Proc. Natl. Acad. Sci. USA 110, 3101-3106 (19 February 2013)

Homeoprotein Signaling in Development, Health, and Disease: A Shaking of Dogmas Offers Challenges and Promises from Bench to Bed
J. Spatazza, E. Di Lullo, A. Joliot, E. Dupont, K. L. Moya, and A. Prochiantz
Pharmacol. Rev. 65, 90-104 (9 January 2013)

Effects of Digesting Chondroitin Sulfate Proteoglycans on Plasticity in Cat Primary Visual Cortex
V. Vorobyov, J. C. F. Kwok, J. W. Fawcett, and F. Sengpiel
J. Neurosci. 33, 234-243 (2 January 2013)

Molecular Mechanisms Underlying Behaviors Related to Nicotine Addiction
M. R. Picciotto, and P. J. Kenny
Cold Spring Harb Perspect Med 3, a012112-a012112 (1 January 2013)

Alpha-1 Adrenergic Receptors Gate Rapid Orientation-Specific Reduction in Visual Discrimination
M. Trevino, S. Frey, and G. Kohr
Cereb Cortex 22, 2529-2541 (1 November 2012)

The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium
X. W. Fu, S. S. Rekow, and E. R. Spindel
Am. J. Physiol. Lung Cell. Mol. Physiol. 303, L661-L668 (15 October 2012)

Treatment of Neurodevelopmental Disorders in Adulthood
E. Castren, Y. Elgersma, L. Maffei, and R. Hagerman
J. Neurosci. 32, 14074-14079 (10 October 2012)

Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction
J. M. Miwa, H. A. Lester, and A. Walz
Physiology 27, 187-199 (1 August 2012)

Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex
M. Beurdeley, J. Spatazza, H. H. C. Lee, S. Sugiyama, C. Bernard, A. A. Di Nardo, T. K. Hensch, and A. Prochiantz
J. Neurosci. 32, 9429-9437 (4 July 2012)

Glutamatergic Synapse Formation is Promoted by {alpha}7-Containing Nicotinic Acetylcholine Receptors
A. F. Lozada, X. Wang, N. V. Gounko, K. A. Massey, J. Duan, Z. Liu, and D. K. Berg
J. Neurosci. 32, 7651-7661 (30 May 2012)

Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment
M. de Groot, J. C. Reijneveld, E. Aronica, and J. J. Heimans
Brain 135, 1002-1016 (1 April 2012)

{alpha}4* Nicotinic Acetylcholine Receptors Modulate Experience-Based Cortical Depression in the Adult Mouse Somatosensory Cortex
C. E. Brown, D. Sweetnam, M. Beange, P. C. Nahirney, and R. Nashmi
J. Neurosci. 32, 1207-1219 (25 January 2012)

Response feedback triggers long-term consolidation of perceptual learning independently of performance gains
J. Dobres, and T. Watanabe
J Vis 12, 9-9 (1 January 2012)

Presynaptic Gating of Postsynaptically Expressed Plasticity at Mature Thalamocortical Synapses
J. A. Blundon, I. T. Bayazitov, and S. S. Zakharenko
J. Neurosci. 31, 16012-16025 (2 November 2011)

{alpha}7-Containing and Non-{alpha}7-Containing Nicotinic Receptors Respond Differently to Spillover of Acetylcholine
D. Stanchev, and P. B. Sargent
J. Neurosci. 31, 14920-14930 (19 October 2011)

Lynx for Braking Plasticity
M. J. Higley, and S. M. Strittmatter
Science 330, 1189-1190 (26 November 2010)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882