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Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis

Science, 15 July 2011
Vol. 333, Issue 6040, p. 339-341
DOI: 10.1126/science.1200940

Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis

  1. Kiichiro Taniguchi1,*,
  2. Reo Maeda1,*,
  3. Tadashi Ando1,
  4. Takashi Okumura1,
  5. Naotaka Nakazawa1,
  6. Ryo Hatori1,
  7. Mitsutoshi Nakamura1,
  8. Shunya Hozumi1,
  9. Hiroo Fujiwara1,
  10. Kenji Matsuno1,2,
  1. 1Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
  2. 2Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
  1. To whom correspondence should be addressed. E-mail: matsuno{at}rs.noda.tus.ac.jp
  1. * These authors contributed equally to this work.

Abstract

Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of the hindgut epithelial tube. Hindgut epithelial cells adopt a LR asymmetric (chiral) cell shape within their plane, and we refer to this cell behavior as planar cell-shape chirality (PCC). Drosophila E-cadherin (DE-Cad) is distributed to cell boundaries with LR asymmetry, which is responsible for the PCC formation. Myosin ID switches the LR polarity found in PCC and in DE-Cad distribution, which coincides with the direction of rotation. An in silico simulation showed that PCC is sufficient to induce the directional rotation of this tissue. Thus, the intrinsic chirality of epithelial cells in vivo is an underlying mechanism for LR asymmetric tissue morphogenesis.

  • Received for publication 26 November 2010.
  • Accepted for publication 10 June 2011.

Citation:

K. Taniguchi, R. Maeda, T. Ando, T. Okumura, N. Nakazawa, R. Hatori, M. Nakamura, S. Hozumi, H. Fujiwara, and K. Matsuno, Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis. Science 333, 339-341 (2011).

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