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ESCRTing DNA at the Cleavage Site During Cytokinesis

Science, 13 April 2012
Vol. 336, Issue 6078, p. 166-167
DOI: 10.1126/science.1221832

ESCRTing DNA at the Cleavage Site During Cytokinesis

  1. Mark Petronczki1,
  2. Frank Uhlmann2
  1. 1Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire, EN6 3LD, UK.
  2. 2Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
  1. E-mail: mark.petronczki{at}cancer.org.uk (M.P.); frank.uhlmann{at}cancer.org.uk (F.U.)

Summary

Collisions are only good business for insurance companies. During cell division, collisions between separating chromosomes and the cytokinetic apparatus, which physically divides the two daughter cells, must be avoided to prevent catastrophic consequences for genome stability (1). Cytokinesis follows the separation of sister genomes, which are pulled to opposite cell poles, and involves splitting the cytoplasm by the ingression of a cleavage furrow followed by a terminal membrane fission event called abscission (2). Recent work has identified a monitoring system that prevents cell separation while chromatin lingers in the division plane (3, 4). At the heart of it lies a conserved protein kinase, Aurora B. On page 220 in this issue, Carlton et al. identify CHMP4C, a subunit of the ESCRT-III (endosomal sorting complex required for transport) complex, as a key target of Aurora B that delays abscission and prevents DNA damage if chromatin bridges persist in human cells (5).

Citation:

M. Petronczki and F. Uhlmann, ESCRTing DNA at the Cleavage Site During Cytokinesis. Science 336, 166-167 (2012).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882