Science/AAAS | Science Signaling: Table of Contents: 8 January 2008; 1 (1)

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About the Cover

8 January 2008
Vol 1, Issue 1

Editors' Choice
Editorial Guides
Perspectives

For all checked items

Editors' Choice

Allergy
An RGS for PI3K: Nancy R. Gough
Sci. Signal. 8 January 2008: ec1.
Regulator of G protein signaling 13 (RGS13) interacts with the p85 subunit of PI3K to inhibit mast cell degranulation. Summary »|

Wnt Signaling
Absence Makes the Wnt Go Stronger: John F. Foley
Sci. Signal. 8 January 2008: ec2.
Cells deficient in cilia exhibit enhanced responses to Wnt3a. Summary »|

Cell Biology
Contraction-Mediated Release of TGF-β1: Nancy R. Gough
Sci. Signal. 8 January 2008: ec3.
Integrin-mediated release of latent TGF-β1 from the extracellular matrix involves the mechanical stress of cell contraction. Summary »|

Ion Channels
Reduced to Activation: Elizabeth M. Adler
Sci. Signal. 8 January 2008: ec4.
Extracellular thioredoxin activates TRPC5 channels and heteromultimers by breaking a disulphide bridge. Summary »|

Calcium Signaling
A STIM for Resting Cells: L. Bryan Ray
Sci. Signal. 8 January 2008: ec5.
A key regulatory protein helps hold constant basal concentrations of calcium in the cell. Summary »|

Immunology
Akirins Clarify NF- ${kappa}$ B Signaling: Nancy R. Gough
Sci. Signal. 8 January 2008: ec6.
A new nuclear player, Akirin, is discovered for the NF- ${kappa}$ B pathway. Summary »|

Neuroscience
Transporting Behavior?: Elizabeth M. Adler
Sci. Signal. 8 January 2008: ec7.
Glial modulation of extracellular glutamate concentration and glutamatergic transmission affects male Drosophila courtship behavior. Summary »|

Neuroscience
Changing Her Ways: Elizabeth M. Adler
Sci. Signal. 8 January 2008: ec8.
Sex peptide receptor, a GPCR, mediates postmating changes in female behavior. Summary »|

EGFR Signaling
Invasion Signal: John F. Foley
Sci. Signal. 8 January 2008: ec9.
GEP100, an activator of the small GTPase Arf6, mediates EGF-dependent tumor cell invasiveness. Summary »|

Neuroscience
Synaptic Metaplasticity: Peter Stern
Sci. Signal. 8 January 2008: ec10.
During continuous sensory stimulation, NMDA receptors in the mouse cortex switch from enhancing synaptic potentiation to opposing it. Summary »|

Evolution
The Ant and the Butterfly: Laura M. Zahn
Sci. Signal. 8 January 2008: ec11.
Because they are coated with a specific chemical, the larvae of a butterfly are adopted and cared for by an ant species, a relationship that shows signs of ongoing coevolution. Summary »|

Editorial Guides

Cell Biology
2007: Signaling Breakthroughs of the Year: Elizabeth M. Adler, John F. Foley, Nancy R. Gough, and L. Bryan Ray
Sci. Signal. 8 January 2008: eg1.
This year's advances span research into the signals that regulate the state of chromatin in the cell nucleus to those signals that modulate the social behavior of organisms. Abstract »| Full Text »| PDF »|

Perspectives

Immunology
Nuclear Ubiquitin Ligases, NF- ${kappa}$ B Degradation, and the Control of Inflammation: Gioacchino Natoli and Susanna Chiocca
Sci. Signal. 8 January 2008: pe1.
The ubiquitination and degradation of NF- ${kappa}$ B complexes in the nucleus provides a mechanism by which pro-inflammatory responses are terminated. Summary »| Full Text »| PDF »|