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Editors' Choice

Nancy R. Gough
8 January 2008: ec1.
Regulator of G protein signaling 13 (RGS13) interacts with the p85 subunit of PI3K to inhibit mast cell degranulation. Abstract »  
John F. Foley
8 January 2008: ec2.
Cells deficient in cilia exhibit enhanced responses to Wnt3a. Abstract »  
Nancy R. Gough
8 January 2008: ec3.
Integrin-mediated release of latent TGF-β1 from the extracellular matrix involves the mechanical stress of cell contraction. Abstract »  
Elizabeth M. Adler
8 January 2008: ec4.
Extracellular thioredoxin activates TRPC5 channels and heteromultimers by breaking a disulphide bridge. Abstract »  
L. Bryan Ray
8 January 2008: ec5.
A key regulatory protein helps hold constant basal concentrations of calcium in the cell. Abstract »  
Nancy R. Gough
8 January 2008: ec6.
A new nuclear player, Akirin, is discovered for the NF-{kappa}B pathway. Abstract »  
Elizabeth M. Adler
8 January 2008: ec7.
Glial modulation of extracellular glutamate concentration and glutamatergic transmission affects male Drosophila courtship behavior. Abstract »  
Elizabeth M. Adler
8 January 2008: ec8.
Sex peptide receptor, a GPCR, mediates postmating changes in female behavior. Abstract »  
John F. Foley
8 January 2008: ec9.
GEP100, an activator of the small GTPase Arf6, mediates EGF-dependent tumor cell invasiveness. Abstract »  
Peter Stern
8 January 2008: ec10.
During continuous sensory stimulation, NMDA receptors in the mouse cortex switch from enhancing synaptic potentiation to opposing it. Abstract »  
Laura M. Zahn
8 January 2008: ec11.
Because they are coated with a specific chemical, the larvae of a butterfly are adopted and cared for by an ant species, a relationship that shows signs of ongoing coevolution. Abstract »  


Editorial Guides

Elizabeth M. Adler, John F. Foley, Nancy R. Gough, and L. Bryan Ray
8 January 2008: eg1.
This year's advances span research into the signals that regulate the state of chromatin in the cell nucleus to those signals that modulate the social behavior of organisms. Abstract »   Full Text »   PDF »  



Gioacchino Natoli and Susanna Chiocca
8 January 2008: pe1.
The ubiquitination and degradation of NF-{kappa}B complexes in the nucleus provides a mechanism by which pro-inflammatory responses are terminated. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882