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Editors' Choice

Nancy R. Gough
11 March 2008: ec88.
Viral, bacterial, and even host DNA trigger processing and release of the proinflammatory mediator interleukin-1β by activating the inflammasome. Abstract »  
L. Bryan Ray
11 March 2008: ec89.
A ligand is identified that activates processing of the β-amyloid precursor protein to control neurogenesis. Abstract »  
John F. Foley
11 March 2008: ec90.
Mesenchymal progenitor cells in the bone marrow are kept in check by Notch signaling, which inhibits their differentiation into osteoblasts. Abstract »  
Elizabeth M. Adler
11 March 2008: ec91.
Human IGF-1 receptor mutations may be associated with a predisposition toward long life. Abstract »  
John F. Foley
11 March 2008: ec92.
Worms stop eating and start resting because of signals such as insulin, cGMP, and TGF-β. Abstract »  
L. Bryan Ray
11 March 2008: ec93.
Competing glycosylation and phosphorylation of a single amino acid in a transcriptional coactivator regulate nutrient and energy sensing pathways and may contribute to diabetes. Abstract »  
Nancy R. Gough
11 March 2008: ec94.
Activation of a mitochondrial protease localized to the intermembrane space appears to be important for survival of immune cells and neurons. Abstract »  
Beverly A. Purnell
11 March 2008: ec95.
A transcriptional corepressor is part of the protein complex that inhibits developmental gene activation in Arabidopsis until the growth hormone auxin triggers its degradation. Abstract »  
Caroline Ash
11 March 2008: ec96.
Mutating a cell-surface virulence protein on strep bacteria stabilizes its structure, minimizing its inflammatory side effects and potentially making it a better vaccine. Abstract »  

 

Perspectives

Rebecca G. Wells and Dennis E. Discher
11 March 2008: pe13.
Extracellular matrix stiffness regulates the equilibrium between storage and release of matrix-bound transforming growth factor-β. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882