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Editors' Choice

Elizabeth M. Adler
25 March 2008: ec107.
TLR4 appears to stimulate TIRAP-MyD88 signaling from the cell surface and to initiate TRAM-TRIF signaling only after internalization. Abstract »  
L. Bryan Ray
25 March 2008: ec108.
A cell cycle–associated kinase phosphorylates the transcription factor FOXO1, which activates transcription of a regulator of mitosis. Abstract »  
John F. Foley
25 March 2008: ec109.
The C. elegans transcription factor SKN-1, whose activity is inhibited by insulin-like signaling, turns on pathways that lead to a longer life span. Abstract »  
Elizabeth M. Adler
25 March 2008: ec110.
Insulin/insulin-like growth factor signaling is associated with regulation of social behavior in honey bees. Abstract »  
Annalisa VanHook
25 March 2008: ec111.
Atoh1 regulation is central to granule cell development and medulloblastoma. Abstract »  
Peter Stern
25 March 2008: ec112.
Pairing of stimuli in hippocampal cells induces secretion of the growth factor BDNF, causing enlargement of individual spines and strengthening of synapses. Abstract »  
Paula A. Kiberstis
25 March 2008: ec113.
One type of non-Hodgkin’s lymphoma is caused by mutations in a scaffolding protein that inappropriately activate an inflammatory signaling pathway. Abstract »  
L. Bryan Ray
25 March 2008: ec114.
The neurotransmitter glutamate contributes to arterial blockage by thrombosis. Abstract »  

 

Editorial Guides

Nancy R. Gough
25 March 2008: eg2.
Four new sections of Science Signaling bring new resources to the cell signaling community. Abstract »   Full Text »   PDF »  

 

Podcasts

Elizabeth M. Adler and Nancy R. Gough
25 March 2008: pc1.
Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Abstract »   Full Text »   Podcast »  
Nancy R. Gough and John F. Foley
25 March 2008: pc2.
Glucose may stimulate the formation of fat tissue in muscle. Abstract »   Full Text »   Podcast »  

 

Meeting Reports

Karlheinz Friedrich, Ottmar Janssen, and Ralf Hass
25 March 2008: mr1.
The 2007 meeting of the Signal Transduction Society focused on results obtained using state-of-the-art imaging methodologies. Abstract »   Full Text »   PDF »  

 

Presentations

Catharina Bertram and Ralf Hass
25 March 2008: pt1.
Two cultured cell systems provide insight into intracellular and extracellular events involved in cellular differentiation and senescence. Abstract »   Full Text »   PDF »   Slideshow »  
Sarah E. Henrickson, Thorsten R. Mempel, Irina B. Mazo, Bai Liu, Maxim N. Artyomov, Huan Zheng, Antonio Peixoto, Michael Flynn, Balimkiz Senman, Tobias Junt, Hing C. Wong, Arup K. Chakraborty, and Ulrich H. von Andrian
25 March 2008: pt2.
History of prior antigenic experience controls T cell activation. Abstract »   Full Text »   PDF »   Slideshow »  
Sonia Waiczies, Ivo Bendix, and Frauke Zipp
25 March 2008: pt3.
Posttranslational lipid modification of RhoA is necessary for T cell migration into the central nervous system during neuroinflammation. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882