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Editors' Choice

L. Bryan Ray
1 April 2008: ec115.
Good nutrition is sensed in the same dopaminergic reward system that processes taste preferences. Abstract »  
Elizabeth M. Adler
1 April 2008: ec116.
Some glial cells generate action potentials. Abstract »  
John F. Foley
1 April 2008: ec117.
The release of hematopoietic stem cells from the bone marrow and their return follow a circadian rhythm. Abstract »  
Annalisa VanHook
1 April 2008: ec118.
Treatment with four cytokines recapitulates serum-driven differentiation of mouse embryonic stem cells. Abstract »  
Nancy R. Gough
1 April 2008: ec119.
To achieve increased production of proteins encoded by genes regulated by IFNs, IFNs stimulate both transcription through JAK/STAT signaling and translation through an Akt to mTOR pathway. Abstract »  
Peter Stern
1 April 2008: ec120.
The widely used insect repellent DEET acts by inhibiting olfactory neurons that respond to odors such as those that attract insects to their hosts. Abstract »  
Peter Stern
1 April 2008: ec121.
The electrical field set up by currents within the synaptic cleft can influence diffusion of negatively charged neurotransmitters such as glutamate and prolong excitatory events. Abstract »  


Editorial Guides

John F. Foley
1 April 2008: eg3.
Multilayered mechanisms control various aspects of gene expression. Abstract »   Full Text »   PDF »  



Xiaodong Cheng
1 April 2008: pe14.
Oncogenic Ras directs a program that epigenetically silences genes that inhibit tumorigenesis. Abstract »   Full Text »   PDF »  
Peter N. Cockerill
1 April 2008: pe15.
Inducible intrachromosomal looping between the tumor necrosis factor-{alpha} (TNF-{alpha}) gene promoter and two NFAT-dependent enhancers activates TNF-{alpha} gene expression. Abstract »   Full Text »   PDF »  
David M. Lonard and Bert W. O’Malley
1 April 2008: pe16.
The critical factor in estrogen-dependent growth of breast cancer cells appears to be the abundance of the coactivator protein SRC-3. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882