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Editors' Choice

L. Bryan Ray
22 April 2008: ec137.
Genetic rewiring of transcriptional regulatory networks in bacteria is surprisingly well tolerated. Abstract »  
John F. Foley
22 April 2008: ec138.
The pseudokinase Ca2+/calmodulin-activated serine-threonine kinase (CASK), which was assumed to be catalytically inactive, has kinase activity in vivo. Abstract »  
Elizabeth M. Adler
22 April 2008: ec139.
Aluminum-containing adjuvants stimulate dendritic cells by means of uric acid. Abstract »  
Valda J. Vinson
22 April 2008: ec140.
Two horseshoe-shaped monomers of an innate immunity receptor bind to double-stranded RNA through carboxyl-terminal dimerization, ultimately triggering inflammation. Abstract »  
Valda J. Vinson
22 April 2008: ec141.
Flagellar proteins from two bacterial species diverge in their coiled-coil regions; only one triggers an immune response, which may have driven their evolutionary divergence. Abstract »  
Nancy R. Gough
22 April 2008: ec142.
When NADPH is decreased, HSCARG appears to inhibit argininosuccinate synthetase to limit nitric oxide production. Abstract »  
Nancy R. Gough
22 April 2008: ec143.
Silencing of the bam gene in Drosophila involves Decapentaplegic (Dpp) signaling and the nuclear membrane protein Otefin. Abstract »  
Annalisa M. VanHook
22 April 2008: ec144.
HIF is required for hypoxia-induced tracheal sprouting in Drosophila but not for normal development. Abstract »  
L. Bryan Ray
22 April 2008: ec145.
Modeling and experiments show that neurons survive during development when neuronal sensitization to survival signals outweighs antagonistic signals for cell death. Abstract »  
Annalisa M. VanHook
22 April 2008: ec146.
Localized regulation of translation may be more widespread than previously thought. Abstract »  
L. Bryan Ray
22 April 2008: ec147.
A developmental signal causes clustering of membrane-associated proteins (including its receptor) at one end of the cell, marking the cell's polarity for directional movement. Abstract »  
John F. Foley
22 April 2008: ec148.
During canonical Wnt signaling, nuclear translocation of β-catenin involves a pathway that includes PI3K, Rac1, and JNK2. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882