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Editors' Choice

Barbara R. Jasny
29 April 2008: ec149.
Patients with schizophrenia carry multiple small deletions and duplications in their DNA that are associated nonrandomly with neuronal signaling and brain development pathways. Abstract »  
L. Bryan Ray
29 April 2008: ec150.
Insect odorant receptors look a bit like GPCRs but appear to function as ligand-gated ion channels. Abstract »  
Elizabeth M. Adler
29 April 2008: ec151.
The bacterial checkpoint protein DisA has diadenylate cyclase activity. Abstract »  
John F. Foley
29 April 2008: ec152.
A scaffold protein well known for its role in neuronal synapse formation is required for efficient activation of naïve CD4+ T cells by dendritic cells. Abstract »  
Beverly A. Purnell and Nancy R. Gough
29 April 2008: ec153.
Sexual reproduction in flowering plants, parasites, and animals has some intriguing similarities. Abstract »  
Annalisa M. VanHook
29 April 2008: ec154.
NO is able to reduce the activity of the Notch intracellular domain in an in vitro model of inflammation. Abstract »  
Peter Stern
29 April 2008: ec155.
Mice can recognize the pheromones from individual mice through unique patterns of receptor activation in the vomeronasal organ. Abstract »  
John F. Foley
29 April 2008: ec156.
The phosphatase SHP-1 inhibits TLR-mediated production of proinflammatory cytokines while enhancing the production of type I interferons. Abstract »  
Elizabeth M. Adler
29 April 2008: ec157.
GRK2 integrates adhesion- and GPCR-based signals to promote epithelial cell migration. Abstract »  
L. Bryan Ray and Stella M. Hurtley
29 April 2008: ec158.
Precise regulation of phosphatidylserine localization is important for engulfment of both viruses and eukaryotic cells. Abstract »  

 

Perspectives

Ernesto Canalis
29 April 2008: pe17.
Notch signaling plays a role in bone remodeling by inhibiting the differentiation of osteoblasts and osteoclasts. Abstract »   Full Text »   PDF »  
Andreas H. Guse
29 April 2008: pe18.
The protozoan parasite Toxoplasma gondii uses a plant-like signaling pathway to exit host cells. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882