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Editors' Choice

L. Bryan Ray
6 May 2008: ec159.
The aryl hydrocarbon receptor, known for binding environmental toxins, regulates the balance of pro- and anti-inflammatory responses in the immune system. Abstract »  
Nancy R. Gough
6 May 2008: ec160.
The noncanonical poly(A) polymerase Star-PAP is part of an RNA processing complex that includes both lipid and protein kinases. Abstract »  
John F. Foley
6 May 2008: ec161.
The activation of Ca2+/CaM-dependent protein kinase II (CaMKII) by reactive oxygen species has important implications for cardiac function. Abstract »  
Paula A. Kiberstis
6 May 2008: ec162.
Mutations in mitochondrial DNA that cause enhanced production of reactive oxygen species can increase the propensity of tumor cells to metastasize. Abstract »  
Elizabeth M. Adler
6 May 2008: ec163.
Tumor cell epithelial-mesenchymal transition in response to hypoxia depends on Notch signaling. Abstract »  
Elizabeth M. Adler
6 May 2008: ec164.
HNP-1 inhibits hepatic glucose production. Abstract »  
Annalisa M. VanHook
6 May 2008: ec165.
The Frizzled planar cell polarity pathway patterns elements oriented along different axes in the same polarized tissue. Abstract »  
Nancy R. Gough
6 May 2008: ec166.
DivK is not only a response regulator for PleC and DivJ but also an allosteric regulator of both kinases. Abstract »  
John F. Foley
6 May 2008: ec167.
Treatment of neurons with oligomeric Aβ42 reduces the abundance of membrane PtdIns(4,5)P2, an effect that is mediated in part by a synaptic phosphatase. Abstract »  
Annalisa M. VanHook
6 May 2008: ec168.
Experiments in a sea anemone suggest that one of the ancestral functions of the FGF pathway may have been inducing sensory organs. Abstract »  
Stephen J. Simpson
6 May 2008: ec169.
A large multiprotein complex detects particulate airborne pollutants that have been taken up by immune cells in the lung and initiates a potent inflammatory response. Abstract »  
L. Bryan Ray
6 May 2008: ec170.
A well-studied kinase is shown to be unexpectedly phosphorylated and inhibited by mitogen-activated protein kinase, and this modification activates cell-survival pathways. Abstract »  
Stephen J. Simpson
6 May 2008: ec171.
A lipoprotein in human blood protects against an African parasite by binding to a parasite receptor and triggering uptake of the lipoprotein, which contains a toxic component. Abstract »  

 

Podcasts

Elizabeth M. Adler and Annalisa M. VanHook
6 May 2008: pc4.
Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Abstract »   Full Text »   Podcast »  

 

Perspectives

Jessica E. Malberg and Lisa M. Monteggia
6 May 2008: pe19.
The neuropeptide VGF appears to play a role in the antidepressant effects of exercise, the neurotrophic factor BDNF, and the neurotransmitter serotonin. Abstract »   Full Text »   PDF »  
W. Ryan Williamson and P. Robin Hiesinger
6 May 2008: pe20.
The morphogen Activin acts as a permissive and local motility restriction signal around individual photoreceptor terminals. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882