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Cover Figure

COVER This week's issue features a Perspective that discusses a number of models that describe how interactions between various molecules on the surfaces of antigen-presenting cells (APCs) and T lymphocytes cause T cell receptor (TCR) triggering. The image shows the clustering of receptors at the immunological synapse formed between an APC and a T cell. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)