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Editors' Choice

L. Bryan Ray
15 January 2008: ec12.
Protons mediate signaling from intestinal cells to surrounding muscle in the worm. Abstract »  
Elizabeth M. Adler
15 January 2008: ec13.
The plant hormone abscisic acid regulates exit of the parasite Toxoplasma gondii from host cells. Abstract »  
John F. Foley
15 January 2008: ec14.
JNK activation mediates nerve growth factor-enhanced secretion in PC12 cells. Abstract »  
John F. Foley
15 January 2008: ec15.
ERKs phosphorylate the enzyme that processes pre-TNF-{alpha} in lipopolysaccharide-stimulated macrophages. Abstract »  
Elizabeth M. Adler
15 January 2008: ec16.
Ceramidase regulation of fly photoreceptor function is cell nonautonomous. Abstract »  
Nancy R. Gough
15 January 2008: ec17.
Deep brain stimulation appears to trigger nonsynaptic release of ATP, which when converted to adenosine contributes to the tremor-reducing effects of this treatment. Abstract »  
Nancy R. Gough
15 January 2008: ec18.
Immunophilins modified for selectivity for FKBP52 also inhibit L-type voltage-dependent calcium channels. Abstract »  
Beverly A. Purnell
15 January 2008: ec19.
Estrogens trigger histone demethylation, which elicits a local DNA oxidative burst that guides initial assembly of the transcription/repair complex. Abstract »  
Stella M. Hurtley
15 January 2008: ec20.
A fluorescent tag specific for a negatively charged lipid shows that its higher concentration in endosomes and lysosomes attracts cationic proteins within the cell. Abstract »  
Paula A. Kiberstis
15 January 2008: ec21.
Experiments in mice show that certain bone marrow cells promote the development of lung cancers by helping blood vessels form within the tumors. Abstract »  
Stephen J. Simpson
15 January 2008: ec22.
In mice, a common histone protein that coats DNA is unexpectedly detected within prostate tumors by the immune system, suggesting a potential therapeutic approach. Abstract »  

 

Perspectives

Aly Karsan
15 January 2008: pe2.
Notch-dependent activation of R-Ras reverses H-Ras–mediated suppression of integrin activity. Abstract »   Full Text »   PDF »  
Fumihito Ono
15 January 2008: pe3.
A dispersing and a clustering pathway for acetylcholine receptors converge on the postsynaptic protein rapsyn in skeletal muscle. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882