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Cover Figure

COVER This week's issue features a Perspective that discusses how the tyrosine kinase focal adhesion kinase (FAK) acts in a kinase-independent manner as a scaffold protein to lead to the degradation of the tumor suppressor protein p53 in the nucleus. The image depicts the degradation of p53 (in orange) by the nuclear proteasome. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882