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Editors' Choice

Nancy R. Gough
20 May 2008: ec181.
Metabotropic glutamate receptors may trigger nuclear calcium signals through a G protein signaling pathway completely localized in the nucleus. Abstract »  
L. Bryan Ray
20 May 2008: ec182.
Variations in cell shape can translate into distinct signaling patterns within a cell. Abstract »  
John F. Foley
20 May 2008: ec183.
Interferon-β produced locally in the central nervous system acts on myeloid cells to protect against inflammation. Abstract »  
Pamela J. Hines
20 May 2008: ec184.
A cadherin molecule on the surface of guidepost neurons in the developing brain marks the pathway for axons to follow from the thalamus to the cortex. Abstract »  
Nancy R. Gough
20 May 2008: ec185.
Glypican-3 in mammals appears to inhibit Hedgehog signaling, whereas in flies glypicans are required for Hedgehog signaling. Abstract »  
Elizabeth M. Adler
20 May 2008: ec186.
The crystal structure of squid rhodopsin sheds light on signaling through GPCRs that interact with Gq. Abstract »  
Annalisa M. VanHook
20 May 2008: ec187.
The morphology of primary cilia in a C. elegans olfactory neuron is shaped by sensory input. Abstract »  
John F. Foley
20 May 2008: ec188.
Notch signaling in CD8+ T cells increases inflammation and airway hyperresponsiveness in a mouse model of asthma. Abstract »  
L. Bryan Ray
20 May 2008: ec189.
Analysis of transcription data and known signaling networks predicts two previously unrecognized regulators of neuronal growth, which were experimentally confirmed. Abstract »  
Annalisa M. VanHook and Nancy R. Gough
20 May 2008: ec190.
A focal adhesion component is required for both outside-in and inside-out integrin signaling. Abstract »  
L. Bryan Ray
20 May 2008: ec191.
Signaling through cyclic adenosine monophosphate determines the amplitude, phase, and period of the mammalian circadian clock and so may be an integral part of the pacemaker. Abstract »  
Pamela J. Hines
20 May 2008: ec192.
In Arabidopsis root tips exposed to high salinity or iron deficiency, clusters of genes are induced that are unique to one or both of these stress responses. Abstract »  

 

Perspectives

William G. Cance and Vita M. Golubovskaya
20 May 2008: pe22.
Focal adhesion kinase acts as a scaffold protein to target p53 for degradation in the nucleus, leading to cell proliferation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882