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Editors' Choice

Nancy R. Gough
27 May 2008: ec193.
A microfluidic device allows calculation of the frequency at which a pathway can faithfully reproduce an input and above which the pathway integrates the input. Abstract »  
John F. Foley
27 May 2008: ec194.
The large number of CD3 ITAM motifs contained within the T cell receptor complex is needed to prevent autoimmunity. Abstract »  
Nancy R. Gough
27 May 2008: ec195.
IRAK4 initiates the response to Toll-like receptor (TLR) signaling, then IRAK1 mediates a transient early phase and IRAK2 mediates a prolonged late phase. Abstract »  
Annalisa M. VanHook
27 May 2008: ec196.
Polyamine regulation of a potassium channel is implicated in migration mediated by {alpha}9-containing integrins. Abstract »  
Elizabeth M. Adler
27 May 2008: ec197.
The effects of estradiol on hypothalamic dendritic morphology involve enhancement of presynaptic glutamate release through nongenomic mechanisms. Abstract »  
L. Bryan Ray
27 May 2008: ec198.
Altered intracellular trafficking of a receptor for sperm protein is implicated in control of meiotic maturation of oocytes in C. elegans. Abstract »  
Annalisa M. VanHook
27 May 2008: ec199.
Activation of Gln3 occurs by two distinct mechanisms, one of which depends on its intracellular localization. Abstract »  
Katrina L. Kelner
27 May 2008: ec200.
When hungry, rodents may optimize their chances of finding food by engaging a food-entrained circadian clock in the brain that takes over from the light-driven clock. Abstract »  
Annalisa M. VanHook
27 May 2008: ec201.
A cell-surface enzyme that cleaves proteins is unexpectedly necessary for sensing when iron levels are low and thereby triggering compensatory absorption of iron from food. Abstract »  
L. Bryan Ray
27 May 2008: ec202.
Thioredoxins--known to be antioxidants--also remove nitrosyl groups from a protease to activate it and may also function in this way in other cellular regulatory systems. Abstract »  


Editorial Guides

Elizabeth M. Adler and John F. Foley
27 May 2008: eg4.
The nature of microbe-host relationships often depends on signaling pathways in the host. Abstract »   Full Text »   PDF »  



Max Dow
27 May 2008: pe23.
Different plant pathogens use similar signaling molecules in distinct ways. Abstract »   Full Text »   PDF »  
Won-Jae Lee
27 May 2008: pe24.
Stimulation of the production of reactive oxygen species in gut epithelial cells by commensal bacteria dampens the host immune response. Abstract »   Full Text »   PDF »  
Florian Wartha and Birgitta Henriques-Normark
27 May 2008: pe25.
Pathogenic microbes are trapped and killed by mast cell– and neutrophil-derived extracellular traps. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882