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COVER This week's Focus Issue, in conjunction with Science's Special Issue on Microbial Ecology, features an Editorial Guide and three Perspectives that discuss how interactions between microbes and their hosts affect signaling pathways in the host. The image shows grape leaves suffering from Pierce's disease, which is caused by the bacterium Xylella fastidiosa. [Image: Fritz Westover, Texas A & M University, Texas Cooperative Extension.]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882