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Editors' Choice

Nancy R. Gough
10 June 2008: ec211.
The kinase Lyn provides a pathway from the growth hormone receptor to extracellular signal-regulated kinase that is independent of the kinase Jak. Abstract »  
Elizabeth M. Adler
10 June 2008: ec212.
Ligand stimulation of PPAR-{delta} triggers KLF5 deSUMOylation, leading to the transcriptional activation of genes involved in lipid oxidation and energy uncoupling. Abstract »  
Nancy R. Gough
10 June 2008: ec213.
The type I subunit of the transforming growth factor-β receptor may be sumoylated. Abstract »  
John F. Foley
10 June 2008: ec214.
NF-{kappa}B activity is required for basal and hypoxia-induced transcription of the gene encoding HIF-1{alpha}. Abstract »  
Annalisa M. VanHook
10 June 2008: ec215.
A signaling pathway that regulates stem cell proliferation in Arabidopsis is independently transduced through two different receptor complexes. Abstract »  
Annalisa M. VanHook
10 June 2008: ec216.
Some bacterial signaling networks are composed of modules of genes that coevolve. Abstract »  
Caroline Ash
10 June 2008: ec217.
Predictable sequences of environmental signals can be exploited by bacteria so that they learn to anticipate future metabolic needs and thereby gain a competitive edge. Abstract »  
Annalisa M. VanHook
10 June 2008: ec218.
A developmental program in Ciona intestinalis suggests a mechanism by which morphological diversity could be generated. Abstract »  
L. Bryan Ray
10 June 2008: ec219.
T cells are differentially affected by distinct spatial presentation of ligands. Abstract »  

 

Perspectives

Bertram Weiss
10 June 2008: pe27.
The guanosine triphosphatase (GTPase) domain of leucine-rich repeat kinase 2 (LRRK2) mediates LRRK2 homodimerization and controls its protein kinase activity. Abstract »   Full Text »   PDF »   Interactive Figures »  
Nathalie Bolduc, Sarah Hake, and David Jackson
10 June 2008: pe28.
A single domain confers different subcellular localizations of the homeodomain protein KN1. Abstract »   Full Text »   PDF »  

 

Teaching Resources

Jing Liu, Ming Cheng Liu, and Kevin K. W. Wang
10 June 2008: tr3.
This pair of animations illustrates how neuronal calpains contribute to synaptic plasticity or neuronal toxicity. Abstract »   Full Text »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882