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Cover Figure

COVER This week's issue features a Perspective that discusses how the GTPase domain of leucine-rich repeat kinase 2 (LRRK2) mediates LRRK2 homodimerization and controls its protein kinase activity. The image shows the structure of the dimeric GTPase domains of human LRRK2, with one monomer in yellow and the other in green, and is based on PDB structure 2ZEJ. [Image: Bertram Weiss, Bayer Schering Pharma AG13342, Berlin, Germany.]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882