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Editors' Choice

L. Bryan Ray
17 June 2008: ec220.
Receptors mediating antiviral responses of the innate and adaptive immune systems act together in an autophagosome-like cellular compartment. Abstract »  
John F. Foley
17 June 2008: ec221.
"Retraining" macrophages to inhibit their NF-{kappa}B activity leads to improved responses against tumors and invading bacteria. Abstract »  
Annalisa M. VanHook
17 June 2008: ec222.
Some of the molecular machinery through which light inhibits secondary metabolism and sexual reproduction in fungi has been identified. Abstract »  
Nancy R. Gough
17 June 2008: ec223.
A complex of Src64B and the RYK receptor Derailed appears to be important for Wnt5-mediated axonal repulsion in the developing fly nervous system. Abstract »  
Nancy R. Gough
17 June 2008: ec224.
VAPB serves as a ligand for Eph receptors, and a mutation in humans that prevents release of this protein and promotes its aggregation is associated with amyotrophic lateral sclerosis. Abstract »  
L. Bryan Ray
17 June 2008: ec225.
Nutrients, specifically amino acids, are sensed by small GTPases, which bind to a signaling complex, moving it close to the nucleus, where it initiates cell growth. Abstract »  
Barbara R. Jasny
17 June 2008: ec226.
A method that identifies pairs of proteins that are 8 nanometers apart produces a map of interacting proteins in living yeast, finding known and previously unknown networks. Abstract »  
Guy Riddihough
17 June 2008: ec227.
Protein complexes that usually assemble on and repair damaged DNA can form at undamaged sites to halt the cell cycle if several of the proteins are first tethered there. Abstract »  
Stephen J. Simpson
17 June 2008: ec228.
In mice, a transcription factor known to participate in secretion is also necessary for induction of lipid synthesis by carbohydrates in the liver. Abstract »  
L. Bryan Ray
17 June 2008: ec229.
Activation of the mitogen-activated protein kinase pathway in a specific brain region specifically decreases alcohol-drinking behaviors in mice. Abstract »  

 

Podcasts

Elizabeth M. Adler and Annalisa M. VanHook
17 June 2008: pc5.
Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Abstract »   Full Text »   Podcast »  

 

Perspectives

Thomas F. Franke
17 June 2008: pe29.
Multiple interacting proteins modulate the activity of the serine/threonine kinase Akt. Abstract »   Full Text »   PDF »  
Ian J. Frew and Wilhelm Krek
17 June 2008: pe30.
The von Hippel-Lindau tumor suppressor controls transcription-dependent and -independent cellular processes. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882