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Cover Figure

COVER This week's issue features a Review that discusses how heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) may function as activated heterotrimers. This is in addition to the well-characterized abilities of dissociated α and βγ subunits to function independently. The image shows the structure of a heterotrimeric G protein, which consists of α (blue), β (purple), and γ (green) subunits and is based on PDB structure 1GP2. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882