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Editors' Choice

Nancy R. Gough
1 July 2008: ec236.
Some volatile and intravenous general anesthetics activate TRPA1 channels to trigger peripheral pain and nerve-mediated inflammation. Abstract »  
Elizabeth M. Adler
1 July 2008: ec237.
The tingling, numbing sensation elicited by Szechuan peppercorns depends on inhibition of K+ leak currents in a subset of sensory neurons. Abstract »  
John F. Foley
1 July 2008: ec238.
Mutant presenilin proteins, which are associated with familial Alzheimer’s disease, enhance IP3 receptor–mediated Ca2+ signaling in neurons. Abstract »  
Elizabeth M. Adler
1 July 2008: ec239.
The odorant-binding protein LUSH appears to be an inactive ligand activated by pheromone binding. Abstract »  
Nancy R. Gough
1 July 2008: ec240.
Shuttling of morphogens with different affinities for an inhibitor and a negative feedback loop for the morphogen with lower affinity allows Xenopus embryos to scale pattern with size. Abstract »  
Annalisa M. VanHook
1 July 2008: ec241.
Establishment of radial polarity in the early C. elegans embryo requires a RhoGAP that is active only in regions of cell contact. Abstract »  
Pamela J. Hines
1 July 2008: ec242.
A fish sensory organ develops when a wave of migrating primordial cells cyclically deposits rosettes of differentiated cells under the influence of fibroblast growth factor. Abstract »  
L. Bryan Ray
1 July 2008: ec243.
β-arrestins appear to link the Hedgehog receptor protein Smoothened to a motor protein that helps transport the receptor to the primary cilium. Abstract »  

 

Perspectives

Azeddine Atfi and Roland Baron
1 July 2008: pe33.
Interactions between p53 and Smads influence the responses to the TGF-β pathway, which may be important for progression of some types of cancer. Abstract »   Full Text »   PDF »  
Philippa Francis-West and Robert Hill
1 July 2008: pe34.
Sonic hedgehog (Shh) is required for both proliferation and specification of cells in the developing limb bud. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882