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Cover Figure

COVER This week's issue features a Review that discusses the metalloproteinase-independent functions of tissue inhibitors of metalloproteinases (TIMPs). The image shows how the binding of TIMP-2 (pink) to the α3β4 integrin inhibits receptor tyrosine kinase activity through the action of the protein tyrosine phosphatase Shp1. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882