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Editors' Choice

Nancy R. Gough
8 July 2008: ec244.
Ligand-specific R-Smads interact with the primary miR-21 transcripts and the DROSHA complex to stimulate processing to the mature miRNA. Abstract »  
Elizabeth M. Adler
8 July 2008: ec245.
Decreased activity of RhoA and destabilization of basal microtubules lead to basement membrane breakdown at the onset of the epithelial-mesenchymal transition during gastrulation. Abstract »  
John F. Foley
8 July 2008: ec246.
Fibroblast growth factor 21 (FGF21), a hormone whose production is triggered by fasting, inhibits growth hormone signaling. Abstract »  
Nancy R. Gough
8 July 2008: ec247.
Nitrosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) leads to its nuclear translocation and the stimulation of nuclear protein acetyltransferases to contribute to apoptosis. Abstract »  
Stella M. Hurtley
8 July 2008: ec248.
When strengthened, individual synapses on dendritic spines contain an activated small regulatory protein, which spreads to nearby spines, possibly altering their sensitivity. Abstract »  
L. Bryan Ray
8 July 2008: ec249.
Analysis of known and theoretical oscillatory circuits in cells shows that those with both negative and positive feedback are more robust and allow frequency control independent of amplitude. Abstract »  
Valda J. Vinson
8 July 2008: ec250.
Myosin I, a motor protein that plays a role in hearing, is a sensitive tension sensor, reacting to small loads (<2 pN) by binding for much longer times to actin. Abstract »  

 

Perspectives

Daniel D. Carson
8 July 2008: pe35.
The cytoplasmic domain of mucin 1 (MUC1) plays numerous roles in intracellular signaling pathways. Abstract »   Full Text »   PDF »  

 

Reviews

William G. Stetler-Stevenson
8 July 2008: re6.
TIMPs can act directly through cell surface receptors or indirectly through modulation of proteases. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882