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Editors' Choice

Elizabeth M. Adler
22 July 2008: ec260.
Signals encountered in the intestine may enable V. cholerae to express virulence factors at precisely the right time and place. Abstract »  
Nancy R. Gough
22 July 2008: ec261.
Binding of the cytokine IL-15 to its receptor is required for secretion. Abstract »  
Annalisa M. VanHook
22 July 2008: ec262.
The emergence of tyrosine kinase signaling systems coincides with the emergence of multicellularity and may have evolved from serine-threonine kinase systems. Abstract »  
John F. Foley
22 July 2008: ec263.
Lipid peroxidation products of {omega}-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) prevent inflammation by inhibiting NF-{kappa}B signaling. Abstract »  
Nancy R. Gough
22 July 2008: ec264.
Analysis of single cells reveals two positive feedback loops in driving cells to divide. Abstract »  
L. Bryan Ray
22 July 2008: ec265.
A newly described type of protein kinase found in the Golgi phosphorylates signaling proteins on amino acids that are destined to be within extracellular domains. Abstract »  
Katrina L. Kelner
22 July 2008: ec266.
A search for genetic modulators of sleep in Drosophila identified a gene encoding a brain protein that is likely secreted and is required for recovery from sleep deprivation. Abstract »  
Guy Riddihough
22 July 2008: ec267.
The bacterial second messenger cyclic di-GMP controls a wide variety of cellular functions by acting on a riboswitch motif in numerous mRNAs. Abstract »  
Stephen J. Simpson
22 July 2008: ec268.
Two transcription factors cooperate to ensure the correct functioning of CD8+ T cells during the response to infection. Abstract »  
L. Bryan Ray
22 July 2008: ec269.
Oxidation of an immunogenic protein during apoptosis helps apoptotic cells avoid activating the adaptive immune system. Abstract »  

 

Reviews

Anita Schwegmann and Frank Brombacher
22 July 2008: re8.
A new drug discovery paradigm focuses on identifying and targeting cellular elements of the host that are exploited by pathogens. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882