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Editors' Choice

L. Bryan Ray
5 August 2008: ec276.
Degradation of one member of a protein complex that forms when a cytokine receptor is activated causes the complex to move to the cytoplasm, triggering the downstream pathway. Abstract »  
Nancy R. Gough
5 August 2008: ec277.
Alternative splicing produces BK channels that alcohol potentiates, and microRNA regulation reduces the abundance of these forms to produce BK channels that are insensitive to alcohol. Abstract »  
John F. Foley
5 August 2008: ec278.
Crosstalk between the glutamate receptor mGluR5 and the epidermal growth factor receptor is required for glutamate-dependent activation of NF-{kappa}B. Abstract »  
Elizabeth M. Adler
5 August 2008: ec279.
Slit promotes development of nonadherent membrane regions to enable cardiac lumen formation. Abstract »  
Annalisa M. VanHook
5 August 2008: ec280.
Induced pluripotent stem cells derived from adult epithelia are produced by reprogramming of differentiated cells. Abstract »  
Katrina L. Kelner
5 August 2008: ec281.
Although a key immune gene is necessary for mice to fight off a broad range of pathogens, in humans it is only required to protect against a few specialized bacteria. Abstract »  
Peter Stern
5 August 2008: ec282.
Pain neurons containing a particular sodium channel respond only to cold, mechanical, and inflammatory pain, not to all painful stimuli as previously assumed. Abstract »  
Katrina L. Kelner
5 August 2008: ec283.
A ribonucleoprotein directs the splicing of the transcript for CD45, a transmembrane tyrosine phosphatase that initiates signaling through antigen receptors. Abstract »  

 

Podcasts

Nancy R. Gough and Annalisa M. VanHook
5 August 2008: pc7.
Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Abstract »   Full Text »   Podcast »  

 

Presentations

Babru B. Samal and Lee E. Eiden
5 August 2008: pt4.
Simulate knocking out one or more components from a pathway to find alternate connections between a stimulus and a target response. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882