05 August 2008
Vol 1, Issue 31
  • Contents

    • Presentation

    • Podcast

    • Editors' Choice

      • Signaling in Time and Place

        Degradation of one member of a protein complex that forms when a cytokine receptor is activated causes the complex to move to the cytoplasm, triggering the downstream pathway.

      • Splicing and Dicing Alcohol Responsiveness

        Alternative splicing produces BK channels that alcohol potentiates, and microRNA regulation reduces the abundance of these forms to produce BK channels that are insensitive to alcohol.

      • Two Pathways Are Better Than One

        Crosstalk between the glutamate receptor mGluR5 and the epidermal growth factor receptor is required for glutamate-dependent activation of NF-κB.

      • Avoiding a Sticky Situation

        Slit promotes development of nonadherent membrane regions to enable cardiac lumen formation.

      • iPS Cell Origins

        Induced pluripotent stem cells derived from adult epithelia are produced by reprogramming of differentiated cells.

      • Human Immunity—Naturally

        Although a key immune gene is necessary for mice to fight off a broad range of pathogens, in humans it is only required to protect against a few specialized bacteria.

      • The Pain Specialists

        Pain neurons containing a particular sodium channel respond only to cold, mechanical, and inflammatory pain, not to all painful stimuli as previously assumed.

      • Splice Factor

        A ribonucleoprotein directs the splicing of the transcript for CD45, a transmembrane tyrosine phosphatase that initiates signaling through antigen receptors.

About The Cover

Cover image expansion

COVER This week's issue features a Podcast that describes how some general anesthetics activate TRPA1 ion channels in the peripheral nervous system, thus triggering postoperative pain. [Image: Jupiter Images]