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Editors' Choice

Elizabeth M. Adler
26 August 2008: ec299.
Cryptochrome appears to play a critical role in fruit fly magnetoreception. Abstract »  
John F. Foley
26 August 2008: ec300.
Antibodies have been developed that differentiate between polyubiquitin chains that target proteins for degradation and those that enhance protein function. Abstract »  
Elizabeth M. Adler
26 August 2008: ec301.
Insights into the differentiation of brown adipocytes may lead to unexplored approaches to treating obesity. Abstract »  
Peter Stern
26 August 2008: ec302.
A mysterious ganglion at the tip of the nose is an olfactory subsystem that senses alarm pheromones in mice. Abstract »  
Caroline Ash
26 August 2008: ec303.
A small, nontoxic antibiotic candidate interferes with bacterial detection of the host and inhibits infection, in a therapeutic approach that may avoid development of resistance. Abstract »  
Katrina L. Kelner
26 August 2008: ec304.
Variations in component levels of the antigen-induced signaling pathway affect the final response of activated immune cells, conferring flexibility on the system. Abstract »  
L. Bryan Ray
26 August 2008: ec305.
For quiescent cells to periodically divide and then rest, a member of the Notch signaling pathway HES1 must be present; this protein is also activated in some tumors. Abstract »  

 

Protocols

Sungsoo Na and Ning Wang
26 August 2008: pl1.
Get detailed instructions for delivering biologically relevant mechanical stress to individual cells and observing the intracellular signaling activities that ensue. Abstract »   Full Text »   PDF »  

 

Presentations

Michel Roberge
26 August 2008: pt5.
Identifying targets of drugs in yeast using genome-wide drug-induced haploinsufficiency is a viable approach to predicting drug targets in humans. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882