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Editors' Choice

John F. Foley
2 September 2008: ec306.
G protein-coupled receptor kinase 5 (GRK5) phosphorylates HDAC5, thus allowing the transcription of genes involved in cardiac hypertrophy. Abstract »  
Elizabeth M. Adler
2 September 2008: ec307.
Microglial signaling factors are critical to inhibition of adult hippocampal neurogenesis by presenilin 1 variants associated with familial Alzheimer's disease. Abstract »  
Nancy R. Gough
2 September 2008: ec308.
Memory is improved in mice that learn during the circadian peak of ERK and cAMP signaling. Abstract »  
Nancy R. Gough
2 September 2008: ec309.
Reversible oxidation of dynein light chain contributes to activation of NF-{kappa}B by stimuli that produce reactive oxygen species. Abstract »  
Annalisa M. VanHook
2 September 2008: ec310.
FGF signaling directs both homeostatic and facultative regeneration in zebrafish fins. Abstract »  
Valda J. Vinson
2 September 2008: ec311.
Circularly arrayed transmembrane helices tilt to facilitate the opening of a bacterial mechanosensitive channel. Abstract »  
Caroline Ash
2 September 2008: ec312.
In addition to an antiseptic function, phenazines—pigmented antibiotics made by bacteria—organize colony structure by activating a superoxidative stress regulator. Abstract »  
Valda J. Vinson
2 September 2008: ec313.
A channel that allows diffusion of metabolites across the mitochondrial outer membrane forms an unusual 19-stranded β barrel with a pore size of about 25 angstroms. Abstract »  


Editorial Guides

Michael B. Yaffe
2 September 2008: eg5.
Science Signaling launches primary research to meet the needs of the signal transduction community. Abstract »   Full Text »   PDF »  


Research Articles

Wenhan Chang, Chialing Tu, Tsui-Hua Chen, Daniel Bikle, and Dolores Shoback
2 September 2008: ra1.
The extracellular calcium-sensing receptor (CaSR) is essential for embryonic and postnatal skeletal development. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Martin Lee Miller, Lars Juhl Jensen, Francesca Diella, Claus Jørgensen, Michele Tinti, Lei Li, Marilyn Hsiung, Sirlester A. Parker, Jennifer Bordeaux, Thomas Sicheritz-Ponten, Marina Olhovsky, Adrian Pasculescu, Jes Alexander, Stefan Knapp, Nikolaj Blom, Peer Bork, Shawn Li, Gianni Cesareni, Tony Pawson, Benjamin E. Turk, Michael B. Yaffe, Søren Brunak, and Rune Linding
2 September 2008: ra2.
Created with both in vitro and in vivo data, NetPhorest is an atlas of consensus sequence motifs for 179 kinases and 104 phosphorylation-dependent binding domains and reveals new insight into phosphorylation-dependent signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Edward M. Brown and Jane B. Lian
2 September 2008: pe40.
Embryonic and postnatal development of the skeleton requires the functions of the extracellular calcium-sensing receptor (CaSR). Abstract »   Full Text »   PDF »  



Renée van Amerongen, Amanda Mikels, and Roel Nusse
2 September 2008: re9.
The traditional classification of Wnts into canonical or noncanonical proteins may be misleading. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882