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Editors' Choice

Nancy R. Gough
9 September 2008: ec314.
In Caenorhabditis elegans, a large noncoding RNA inhibits the complex that produces small RNAs. Abstract »  
John F. Foley
9 September 2008: ec315.
The assembly of scaffold proteins and ERK dimers is required for the activation of cytoplasmic, but not nuclear, substrates. Abstract »  
Nancy R. Gough
9 September 2008: ec316.
A ligand may not be necessary for the nuclear receptor PPAR{gamma} to promote adipogenesis. Abstract »  
Elizabeth M. Adler
9 September 2008: ec317.
Neurogenin 2 transcriptionally activates the small GTP-binding protein Rnd2 to regulate migration of cortical neurons. Abstract »  
Elizabeth M. Adler
9 September 2008: ec318.
Type IV collagens influence localization of the morphogen Dpp in Drosophila embryos and ovaries. Abstract »  
L. Bryan Ray
9 September 2008: ec319.
The interaction of the signaling molecule Wnt with its receptor triggers accumulation of a lipid regulator, which stimulates phosphorylation of the receptor and cellular responses. Abstract »  
Paula A. Kiberstis
9 September 2008: ec320.
In patients with colorectal cancer, one allele of the transforming growth factor–β gene produces less mRNA and thus less protein, a likely contributor to disease risk. Abstract »  
L. Bryan Ray
9 September 2008: ec321.
Crystal structures reveal how SH2 protein interaction domains can both enhance and inhibit activity of cytoplasmic tyrosine kinases. Abstract »  

 

Research Articles

Elisa Ciraolo, Manuela Iezzi, Romina Marone, Stefano Marengo, Claudia Curcio, Carlotta Costa, Ornella Azzolino, Cristiano Gonella, Cristina Rubinetto, Haiyan Wu, Walter Dastrù, Erica L. Martin, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Letizia Lanzetti, Piero Musiani, Thomas Rückle, Christian Rommel, Jonathan M. Backer, Guido Forni, Matthias P. Wymann, and Emilio Hirsch
9 September 2008: ra3.
The phosphoinositide 3-kinase p110β subunit has noncatalytic functions; its catalytic activity is pertinent to both diabetes and cancer. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Harish Shankaran and H. Steven Wiley
9 September 2008: pe41.
Computational modeling of protein localization dynamics yields new information about Smad signaling. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882