Contents

09 September 2008
Vol 1, Issue 36
  • Contents

    • Research Article

      • Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

        The phosphoinositide 3-kinase p110β subunit has noncatalytic functions; its catalytic activity is pertinent to both diabetes and cancer.

    • Perspective

    • Editors' Choice

      • Big Brother's a Bully

        In Caenorhabditis elegans, a large noncoding RNA inhibits the complex that produces small RNAs.

      • What Are Dimers Good For?

        The assembly of scaffold proteins and ERK dimers is required for the activation of cytoplasmic, but not nuclear, substrates.

      • Ligand Not Required?

        A ligand may not be necessary for the nuclear receptor PPARγ to promote adipogenesis.

      • Getting to the Right Place

        Neurogenin 2 transcriptionally activates the small GTP-binding protein Rnd2 to regulate migration of cortical neurons.

      • Signaling from the Right Place

        Type IV collagens influence localization of the morphogen Dpp in Drosophila embryos and ovaries.

      • Wnt Receptor Signaling

        The interaction of the signaling molecule Wnt with its receptor triggers accumulation of a lipid regulator, which stimulates phosphorylation of the receptor and cellular responses.

      • Quantity, Not Just Quality, Matters

        In patients with colorectal cancer, one allele of the transforming growth factor–β gene produces less mRNA and thus less protein, a likely contributor to disease risk.

      • Multifunctional SH2 Domains

        Crystal structures reveal how SH2 protein interaction domains can both enhance and inhibit activity of cytoplasmic tyrosine kinases.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that investigates both the noncatalytic and catalytic functions of the p110β subunit of phosphoinositide 3-kinase (PI3K). The catalytic activity of PI3K p110β plays a role in diabetes and cancer. The image shows insulin (red) and glucagon (green) immunofluorescence in pancreatic islets from mice expressing a catalytically inactive form of PI3K p110β. [Image: Elisa Ciraolo, University of Torino, Italy]