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Cover Figure

COVER This week's issue features a Research Article that investigates both the noncatalytic and catalytic functions of the p110β subunit of phosphoinositide 3-kinase (PI3K). The catalytic activity of PI3K p110β plays a role in diabetes and cancer. The image shows insulin (red) and glucagon (green) immunofluorescence in pancreatic islets from mice expressing a catalytically inactive form of PI3K p110β. [Image: Elisa Ciraolo, University of Torino, Italy]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882