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Editors' Choice

Elizabeth M. Adler
16 September 2008: ec322.
Strigolactones inhibit lateral branching in plants. Abstract »  
Nancy R. Gough
16 September 2008: ec323.
The fimbriae of the bacteria that cause gingivitis promote the interaction of Toll-like receptor 2 (TLR2) and chemokine receptor CXCR4 to inhibit innate immunity. Abstract »  
L. Bryan Ray
16 September 2008: ec324.
Cell cycle-dependent phosphorylation of the phosphatase SHP-1 results in proteolytic cleavage and movement out of the nucleus. Abstract »  
Stella M. Hurtley
16 September 2008: ec325.
A tumor suppressor is shown to control the degradation of a central protein regulator of cell proliferation. Abstract »  
Nancy R. Gough
16 September 2008: ec326.
Differential requirements for receptor endocytosis and delivery to the perinuclear region for activation of STAT3. Abstract »  
Elizabeth M. Adler
16 September 2008: ec327.
The p75 neurotrophin receptor interacts with ephrin-As to mediate their reverse signaling. Abstract »  
Stella M. Hurtley
16 September 2008: ec328.
The synaptic vesicle protein that mediates membrane fusion during exocytosis also regulates the rate and extent of this process by controlling vesicle tethering. Abstract »  


Research Articles

Christopher T. Veldkamp, Christoph Seibert, Francis C. Peterson, Norberto B. De la Cruz, John C. Haugner, III, Harihar Basnet, Thomas P. Sakmar, and Brian F. Volkman
16 September 2008: ra4.
Solving the structure of the chemokine SDF-1 bound to an extracellular domain of its receptor CXCR4 has illustrated the basis of receptor sulfotyrosine recognition by chemokines and led to the discovery of an inhibitor of leukocyte chemotaxis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Mohamed Kodiha, Claire M. Brown, and Ursula Stochaj
16 September 2008: pl2.
High-throughput screening and MetaXpress software modules can be adapted to quantify the subcellular localization of fluorescently labeled molecules. Abstract »   Full Text »   PDF »  



Michael D. Allen, Lisa M. DiPilato, Bharath Ananthanarayanan, Robert H. Newman, Qiang Ni, and Jin Zhang
16 September 2008: pt6.
Engineered fluorescent reporters allow researchers to follow subcellular activities of signaling components in real time in live cells. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882