23 September 2008
Vol 1, Issue 38
  • Contents

    • Research Article

    • Perspective

    • Podcast

    • Editors' Choice

      • A Two-Way Street

        Tumorigenesis in hedgehog-secreting cancers depends on reciprocal signals between the cancer cells and their stromal environment.

      • Quality Counts

        Whether T cell receptors in the central region of the immunological synapse signal or are degraded depends on the strength of the antigenic stimulus.

      • Activity Around Plaques

        In a mouse model of Alzheimer's disease, neurons close to the characteristic deposits of amyloid show high activity, in contrast to the overall reduction in brain function.

      • Dopaminergic Synapse Plasticity

        When a rat learns to associate a cue with a reward, dopamine-containing neurons in the midbrain acquire an enhanced response to that cue through the action of glutamate.

      • XISTing Synergy

        X chromosome inactivation in stem cells is reversed, a step in allowing them to become pluripotent, when three factors repress the inactivation RNA.

      • Fat Talk

        A fatty acid from adipose tissue acts as a hormone to control systemic metabolism.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that demonstrates that the ubiquitin ligase Nedd4 is essential for proper functioning of the insulin-like growth factor 1 (IGF-1) and insulin pathways in mice, thus positively influencing animal growth. When Nedd4 is absent, Grb10 and IGF-1 receptors colocalize intracellularly and the receptors do not appear at the cell surface. The image shows a Nedd4-deficient mouse embryonic fibroblast stained for the IGF-1 receptor (red) and Grb10 (green). [Image: Baoli Yang, University of Iowa, USA]