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Editors' Choice

Elizabeth M. Adler
23 September 2008: ec329.
Tumorigenesis in hedgehog-secreting cancers depends on reciprocal signals between the cancer cells and their stromal environment. Abstract »  
John F. Foley
23 September 2008: ec330.
Whether T cell receptors in the central region of the immunological synapse signal or are degraded depends on the strength of the antigenic stimulus. Abstract »  
Stella M. Hurtley
23 September 2008: ec331.
In a mouse model of Alzheimer's disease, neurons close to the characteristic deposits of amyloid show high activity, in contrast to the overall reduction in brain function. Abstract »  
Peter Stern
23 September 2008: ec332.
When a rat learns to associate a cue with a reward, dopamine-containing neurons in the midbrain acquire an enhanced response to that cue through the action of glutamate. Abstract »  
Guy Riddihough
23 September 2008: ec333.
X chromosome inactivation in stem cells is reversed, a step in allowing them to become pluripotent, when three factors repress the inactivation RNA. Abstract »  
Annalisa M. VanHook
23 September 2008: ec334.
Apoptosis creates mechanical force that helps drive morphogenesis in Drosophila. Abstract »  
L. Bryan Ray
23 September 2008: ec335.
A fatty acid from adipose tissue acts as a hormone to control systemic metabolism. Abstract »  


Research Articles

Xiao R. Cao, Nancy L. Lill, Natasha Boase, Peijun P. Shi, David R. Croucher, Hongbo Shan, Jing Qu, Eileen M. Sweezer, Trenton Place, Patricia A. Kirby, Roger J. Daly, Sharad Kumar, and Baoli Yang
23 September 2008: ra5.
Nedd4 acts through Grb10 to enhance insulin-like growth factor signaling and control animal growth. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Elizabeth M. Adler, Nancy R. Gough, and Annalisa M. VanHook
23 September 2008: pc8.
Bacteria secrete factors that regulate genes that contribute to virulence. Abstract »   Full Text »   Podcast »  



Carol M. Troy and Elena M. Ribe
23 September 2008: pe42.
Both mitochondrial-dependent and -independent cell death pathways are mediated by caspase-2. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882