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COVER This week's issue features a Research Article that demonstrates that the ubiquitin ligase Nedd4 is essential for proper functioning of the insulin-like growth factor 1 (IGF-1) and insulin pathways in mice, thus positively influencing animal growth. When Nedd4 is absent, Grb10 and IGF-1 receptors colocalize intracellularly and the receptors do not appear at the cell surface. The image shows a Nedd4-deficient mouse embryonic fibroblast stained for the IGF-1 receptor (red) and Grb10 (green). [Image: Baoli Yang, University of Iowa, USA]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882