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Editors' Choice

Nancy R. Gough
30 September 2008: ec336.
Select drugs that inhibit β-adrenergic receptor-mediated activation of G proteins stimulate signaling through β-arrestin. Abstract »  
L. Bryan Ray
30 September 2008: ec337.
Pheromone signaling depends on social context. Abstract »  
John F. Foley
30 September 2008: ec338.
Phosphorylation of serine residues within a short motif triggers the nuclear translocation of various signaling proteins in a nuclear localization signal–independent manner. Abstract »  
Elizabeth M. Adler
30 September 2008: ec339.
Studies by two groups converge to implicate the cyclin-dependent kinase CDK8 in the pathogenesis of colorectal cancer. Abstract »  
Paula A. Kiberstis
30 September 2008: ec340.
Genomic analyses identify genes disrupted in pancreatic tumors and glioblastoma multiforme. Abstract »  
Paula A. Kiberstis
30 September 2008: ec341.
In mice, normal mammary cells can colonize the lung, suggesting that metastases might arise from displaced normal cells acquiring genetic changes that confer malignancy. Abstract »  
Paula A. Kiberstis
30 September 2008: ec342.
Newborn pigs carrying a mutated copy of the gene defective in cystic fibrosis exhibit many features of the human disease and may provide fresh insights for therapy. Abstract »  
Valda J. Vinson
30 September 2008: ec343.
The receptor that binds antigens in jawless vertebrates differs from the immunoglobulins of jawed vertebrates and uses a variable concave surface and carboxyl terminal for recognition. Abstract »  


Research Articles

Ursula Schenk, Astrid M. Westendorf, Enrico Radaelli, Anna Casati, Micol Ferro, Marta Fumagalli, Claudia Verderio, Jan Buer, Eugenio Scanziani, and Fabio Grassi
30 September 2008: ra6.
Pannexin hemichannel–mediated release of ATP provides an autocrine, costimulatory signal for T cell activation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Marie Evangelista, Tze Yang Lim, James Lee, Leon Parker, Amir Ashique, Andrew S. Peterson, Weilan Ye, David P. Davis, and Frederic J. de Sauvage
30 September 2008: ra7.
Cdc2l1is a component of the Hh signaling pathway and opposes the activity of the negative regulator Sufu. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Nate P. Hoverter and Marian L. Waterman
30 September 2008: pe43.
Recognition of a nonclassical Wnt-response element by the transcription factor TCF results in β-catenin acting as a transcriptional repressor of certain Wnt target genes. Abstract »   Full Text »   PDF »  



Rebekka Krumbach, Stuart Bloor, Grigory Ryzhakov, and Felix Randow
30 September 2008: pt7.
A forward genetic screen in immortalized cells identifies NF-{kappa}B signaling components required to transduce signals from Toll-like receptors. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882