COVER This week's issue features a Research Article that demonstrates how ATP, released through pannexin hemichannels, signals in an autocrine fashion through purinergic receptors on activated T cells to provide a costimulatory signal. The authors showed that inhibition of ATP signaling reduced inflammation in mouse models of diabetes and inflammatory bowel disease. The image shows a stained section of colon from a healthy mouse, with goblet cells (pink droplets) lining colonic crypts. [Image: Enrico Radaelli, University of Milan, Italy]

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