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Editors' Choice

Elizabeth M. Adler
29 January 2008: ec31.
GABA regulates stem cell proliferation through a pathway that uses components of the DNA damage checkpoint response. Abstract »  
Guy Riddihough
29 January 2008: ec32.
A kinase that regulates chromosome segregation to daughter cells during metaphase is confined to the inner centromere through its interactions with other centromeric proteins. Abstract »  
John F. Foley
29 January 2008: ec33.
Focal adhesion kinase acts as a scaffold protein in the nucleus to target p53 for degradation and promote cell proliferation. Abstract »  
Stephen J. Simpson
29 January 2008: ec34.
Signals coming into the T cell are coordinated by two scaffolding proteins, which determine whether the cell will be activated or permanently shut down. Abstract »  
John F. Foley
29 January 2008: ec35.
JNK regulates the phosphorylation status and trafficking of AMPA-type glutamate receptors in response to neuronal activity. Abstract »  
Nancy R. Gough
29 January 2008: ec36.
Crosstalk between DAP12-coupled receptors and the IFN-{alpha} receptor enhance activation of STAT1 by IFN-{alpha}. Abstract »  
L. Bryan Ray
29 January 2008: ec37.
Opposite effects of the same receptor on cell migration are explained by coupling to either of two distinct tyrosine kinases. Abstract »  
Elizabeth M. Adler
29 January 2008: ec38.
VGLUT3 is critical to hearing and involved in regulation of cortical excitability. Abstract »  
L. Bryan Ray
29 January 2008: ec39.
Modeling the dynamics of the osmotic stress response in yeast reveals an unexpected, rapid nontranscriptional mechanism that may involve glycerol transport. Abstract »  
Beverly A. Purnell
29 January 2008: ec40.
A yeast transcription factor binds onto and off its promoter rapidly, controlling initiation, but also shows a 30-minute cycle as the number of accessible promoters varies. Abstract »  

 

Perspectives

Adolfo Saiardi and Shamshad Cockcroft
29 January 2008: pe5.
Studies of ITPK1 reveal subtle interconnections between simple metabolism and regulation of a signaling event. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882