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Editors' Choice

Elizabeth M. Adler
7 October 2008: ec344.
Spontaneous and evoked glutamate release may activate different populations of NMDA receptors. Abstract »  
Nancy R. Gough
7 October 2008: ec345.
L-DOPA, an intermediate in melanin synthesis, stimulates an orphan G protein-coupled receptor to trigger release of a trophic factor from the retinal pigmented epithelia. Abstract »  
L. Bryan Ray
7 October 2008: ec346.
A protein associated with protein transport machinery in the endoplasmic reticulum appears to function in signaling detection of viral infection. Abstract »  
Annalisa M. VanHook
7 October 2008: ec347.
EGFR and EGFRvIII activate target gene expression through distinct mechanisms. Abstract »  
Nancy R. Gough
7 October 2008: ec348.
TGF-β signals through the type I receptor to trigger Lys63-linked ubiquitylation and activation of the kinase TAK1. Abstract »  
Elizabeth M. Adler
7 October 2008: ec349.
Hypothalamic IKKβ-NF-{kappa}B signaling plays a critical role in the metabolic response to overnutrition. Abstract »  
L. Bryan Ray
7 October 2008: ec350.
In worms, lipid signaling at the mitochondria is necessary for the germ-cell death that follows radiation damage but not for normal developmental cell death. Abstract »  
Valda J. Vinson
7 October 2008: ec351.
The stressosome, a huge multiprotein complex, has a virus capsid–like core and variable extensions that detect and integrate signals to activate the stress response. Abstract »  
Annalisa M. VanHook
7 October 2008: ec352.
Chemokine signaling is required for migration of endoderm in the zebrafish embryo, not as a chemoattractant but as a regulator of cell adhesion. Abstract »  

 

Podcasts

Nancy R. Gough and John F. Foley
7 October 2008: pc9.
The bacteria that cause periodontitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. Abstract »   Full Text »   Podcast »  

 

Presentations

John M. Tarbell and Eno E. Ebong
7 October 2008: pt8.
A complex extracellular network of proteoglycans communicates mechanical stress to endothelial cells. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882