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Editors' Choice

L. Bryan Ray
14 October 2008: ec353.
A receptor senses glucose and contributes to metabolic regulation in the fruit fly. Abstract »  
Elizabeth M. Adler
14 October 2008: ec354.
Succinate signals through a G protein-coupled receptor to promote retinal angiogenesis. Abstract »  
Nancy R. Gough
14 October 2008: ec355.
Excess light changes the redox status of the chloroplast plastoquinone pool, which triggers both responses involved in acclimation to the light and pathogen defense. Abstract »  
John F. Foley
14 October 2008: ec356.
By increasing the half-lives of peptide-MHC complexes on dendritic cells, TLR ligands lead to increased T cell receptor activation in CD8+ T cells. Abstract »  
Stella M. Hurtley
14 October 2008: ec357.
Herpes virus in neurons can be kept in a latent state by T cells, which release granzyme B, an inhibitor of a protein necessary for viral gene expression. Abstract »  
Katrina L. Kelner
14 October 2008: ec358.
A protein in T regulatory cells controls their ability to dampen activation of the immune system by antigen-presenting cells, preventing autoimmune disease. Abstract »  
Elizabeth M. Adler
14 October 2008: ec359.
Proteolytic activation of epithelial sodium channels is inhibited by increased intracellular sodium. Abstract »  


Research Articles

Severine Chaumont, Vincent Compan, Estelle Toulme, Esther Richler, Gary D. Housley, Francois Rassendren, and Baljit S. Khakh
14 October 2008: ra8.
Optics and electrophysiology reveal the dynamics of an ATP-gated ion channel signaling complex. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ingrid V. Lund, Yinghui Hu, YogendraSinh H. Raol, Rebecca S. Benham, Ramona Faris, Shelley J. Russek, and Amy R. Brooks-Kayal
14 October 2008: ra9.
BDNF regulates a GABA receptor subunit through the repressor ICER. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Hongbo Chi and Richard A. Flavell
14 October 2008: pe44.
Toll-like receptor signaling is inhibited by acetylated MKP-1, a mitogen-activated protein kinase phosphatase. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882