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Editors' Choice

John F. Foley
21 October 2008: ec360.
Vertebrate Hedgehog proteins bind to cell-surface proteins in a manner different from that of their Drosophila counterparts. Abstract »  
Katrina L. Kelner
21 October 2008: ec361.
In the worm C. elegans, sensory neurons surprisingly can inhibit innate immune responses, in part through the mitogen-activated protein kinase (MAPK) signaling pathway. Abstract »  
Nancy R. Gough
21 October 2008: ec362.
The MAPKKK MLK3 appears to interact with a Rho guanine nucleotide exchange factor to dampen G{alpha}q signaling. Abstract »  
L. Bryan Ray
21 October 2008: ec363.
Data from an RNAi screen combined with genetic interaction analysis allows construction of a comprehensive kinase cellular signaling network in Drosophila. Abstract »  
Elizabeth M. Adler
21 October 2008: ec364.
Lrp4 acts as an agrin receptor that enables the agrin-dependent activation of MuSK. Abstract »  
Valda J. Vinson
21 October 2008: ec365.
Two allosterically regulated proteins can be engineered to interact so that when light activates one it triggers the enzymatic output (dihydrofolate reductase) of the other. Abstract »  
L. Bryan Ray
21 October 2008: ec366.
Bacteria that act together like a multicellular organism have a diverse set of kinases like those of eukaryotic organisms. Abstract »  


Editorial Guides

Nancy R. Gough
21 October 2008: eg6.
The consequences of various input signals must first be understood to gain a systems-level explanation of signaling networks. Abstract »   Full Text »   PDF »  


Research Articles

Ali Abdi, Mehdi Baradaran Tahoori, and Effat S. Emamian
21 October 2008: ra10.
An engineering approach reveals the weakest links in cellular signaling networks. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  Preview PDF »  



Kyle P. Chiang and Tom W. Muir
21 October 2008: pe45.
New techniques take advantage of chemistry to investigate signal transduction mechanisms in the cell. Abstract »   Full Text »   PDF »  
Henrik G. Dohlman
21 October 2008: pe46.
The location of a scaffolding protein determines whether activation of MAPK signaling in yeast will produce a graded or binary response. Abstract »   Full Text »   PDF »  
Timothy C. Elston
21 October 2008: pe47.
Monitoring the response to periodic input signals reveals dynamic properties of a MAPK pathway. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882