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Editors' Choice

Paula A. Kiberstis
28 October 2008: ec367.
Hydrogen sulfide gas regulates blood pressure and blood vessel function in mice. Abstract »  
L. Bryan Ray
28 October 2008: ec368.
Adenylyl cyclase molecules appear to shout their message to neighboring inositol 1,4,5-trisphosphate receptors. Abstract »  
Elizabeth M. Adler
28 October 2008: ec369.
Retinoic acid increases synaptic strength in a homeostatic response to inactivity through a mechanism involving localized protein synthesis. Abstract »  
Nancy R. Gough
28 October 2008: ec370.
Seed germination involves a complex interplay between gibberellic acid signaling and abscisic acid signaling that is mediated by transcriptional repressors. Abstract »  
Katrina L. Kelner
28 October 2008: ec371.
A transmembrane protein induced in cytokine-treated bronchial epithelial cells seems to be a long-sought primary carrier of a voltage- and calcium-dependent chloride current. Abstract »  
Pamela J. Hines
28 October 2008: ec372.
A membrane kinase regulates the number of stem cells in the main tip of the root as well as the de novo generation of stem cells in new laterally projecting roots. Abstract »  
Guy Riddihough
28 October 2008: ec373.
The damaged regions of DNA are recruited to the peripheral regions of the nucleus by a complex of nuclear-pore and ubiquitin-modifying proteins, where it is repaired. Abstract »  


Editorial Guides

Michael B. Yaffe
28 October 2008: eg7.
Biologists discover that mathematics can reveal the complexity of cellular signaling networks. Abstract »   Full Text »   PDF »  


Journal Club

Harish P. Janardhan
28 October 2008: jc2.
Interactions between HIF-1{alpha} and C/EBP{alpha} may mediate reciprocal functional effects. Abstract »   Full Text »   PDF »  



Rune Linding and Annalisa M. VanHook
28 October 2008: pc10.
Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Abstract »   Full Text »   Podcast »  


Research Articles

Laura Helming, Elena Tomasello, Themis R. Kyriakides, Fernando O. Martinez, Toshiyuki Takai, Siamon Gordon, and Eric Vivier
28 October 2008: ra11.
Signaling through the DAP12 adaptor triggers a gene expression profile that makes macrophages competent to fuse and form multinucleated giant cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Giuseppe Maulucci, Valentina Labate, Marina Mele, Emiliano Panieri, Giuseppe Arcovito, Tommaso Galeotti, Henrik Østergaard, Jakob R. Winther, Marco De Spirito, and Giovambattista Pani
28 October 2008: pl3.
Measure and visualize intracellular changes in redox state. Abstract »   Full Text »   PDF »   Software »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882