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Editors' Choice

Wei Wong
11 November 2008: ec381.
Endothelial cells preassemble tetraspanins and adhesion receptors in microdomains that cluster around the docking structures for adhering leukocytes. Abstract »  
Nancy R. Gough
11 November 2008: ec382.
Stim appears to trigger calcium-induced calcium release by inducing tetramerization of the pore-forming Orai subunits. Abstract »  
Annalisa M. VanHook
11 November 2008: ec383.
Selective inhibition of CDK1 is sufficient to induce endoreduplication in mammalian trophoblast giant cells. Abstract »  
L. Bryan Ray
11 November 2008: ec384.
Too much stress is bad, particularly when one stress pathway inhibits function of another. Abstract »  
John F. Foley
11 November 2008: ec385.
GSK-3β inhibits the production of IFN-β by macrophages treated with LPS. Abstract »  
Annalisa VanHook
11 November 2008: ec386.
The reproductive system affects life span in C. elegans by regulating fat metabolism. Abstract »  
Wei Wong
11 November 2008: ec387.
Growth of the embryonic stem in Arabidopsis thaliana is controlled by a gene that functions downstream of the circadian clock and light signaling pathways. Abstract »  
L. Bryan Ray
11 November 2008: ec388.
A method that determines the half-lives of all cellular proteins has been used to identify targets of a ubiquitin ligase that controls the cell cycle through protein degradation. Abstract »  
Pamela J. Hines
11 November 2008: ec389.
Regeneration in the central nervous system is impeded by inhibitory receptors that recognize myelin-embedded proteins. Abstract »  



Michael B. Major, Randall T. Moon, and Annalisa M. VanHook
11 November 2008: pc11.
Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Abstract »   Full Text »   Podcast »  


Research Articles

Michael B. Major, Brian S. Roberts, Jason D. Berndt, Shane Marine, Jamie Anastas, Namjin Chung, Marc Ferrer, XianHua Yi, Cristi L. Stoick-Cooper, Priska D. von Haller, Lorna Kategaya, Andy Chien, Stephane Angers, Michael MacCoss, Michele A. Cleary, William T. Arthur, and Randall T. Moon
11 November 2008: ra12.
Integration of protein-protein interaction networks and human genome-wide RNAi screens produces mechanistic insight into Wnt/β-catenin signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Marie-Hélène Blanchet, J. Ann Le Good, Viola Oorschot, Stéphane Baflast, Gabriella Minchiotti, Judith Klumperman, and Daniel B. Constam
11 November 2008: ra13.
Cripto facilitates ALK4 signaling by attenuating intraendosomal sorting of internalized Nodal. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882