18 November 2008
Vol 1, Issue 46
  • Contents

    • Editorial Guide

    • Perspectives

    • Editors' Choice

      • Under Cover

        Binding of CD3ε subunits to the plasma membrane shields critical residues from tyrosine kinases, thus preventing inadvertent T cell activation.

      • Dscam’s Double Duty

        The cell adhesion molecule Dscam is also a netrin receptor.

      • Process of Differentiation

        Nuclear translocation of the intracellular domain of the Wnt receptor Ryk is required for the differentiation of neural progenitor cells into neurons.

      • Surviving Lean Times

        An acetylation switch controls the activity of CRTC2 in regulating the hepatic gluconeogenic program in response to fasting.

      • Meaningful Fluctuations

        Oscillations in MAPK activity in pheromone-stimulated yeast are linked to the formation of multiple mating projections.

      • NO Switch in Lung Inflammation

        S-nitrosylation of a lung surfactant protein determines whether it has pro- or anti-inflammatory effects.

      • To Be or Not to Be

        Positive and negative developmental signals that determine the locations of gas-exchanging leaf pores converge on a specific domain within a transcription factor.

      • Ubiquitin’s Pup(py)?

        A prokaryotic version of ubiquitin, a eukaryotic tag for protein degradation, is linked to lysines in prokaryotic proteins destined for destruction, a process called pupylation.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective about mechanisms by which proteins that shuttle between the nucleus and cytoplasm regulate TGF-β signaling through Smads. [Image: Christopher Bickel, AAAS]