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Editors' Choice

John F. Foley
18 November 2008: ec390.
Binding of CD3{varepsilon} subunits to the plasma membrane shields critical residues from tyrosine kinases, thus preventing inadvertent T cell activation. Abstract »  
Stella M. Hurtley
18 November 2008: ec391.
An endogenous inhibitor of immune cell adhesion dampens recruitment of immune cells to sites of inflammation. Abstract »  
Annalisa M. VanHook
18 November 2008: ec392.
The cell adhesion molecule Dscam is also a netrin receptor. Abstract »  
John F. Foley
18 November 2008: ec393.
Nuclear translocation of the intracellular domain of the Wnt receptor Ryk is required for the differentiation of neural progenitor cells into neurons. Abstract »  
Elizabeth M. Adler
18 November 2008: ec394.
Ceramide decreases the abundance of cell surface nutrient transporters to elicit cell death. Abstract »  
Nancy R. Gough
18 November 2008: ec395.
An acetylation switch controls the activity of CRTC2 in regulating the hepatic gluconeogenic program in response to fasting. Abstract »  
Wei Wong
18 November 2008: ec396.
Oscillations in MAPK activity in pheromone-stimulated yeast are linked to the formation of multiple mating projections. Abstract »  
L. Bryan Ray
18 November 2008: ec397.
S-nitrosylation of a lung surfactant protein determines whether it has pro- or anti-inflammatory effects. Abstract »  
Pamela J. Hines
18 November 2008: ec398.
Positive and negative developmental signals that determine the locations of gas-exchanging leaf pores converge on a specific domain within a transcription factor. Abstract »  
Stella M. Hurtley
18 November 2008: ec399.
A prokaryotic version of ubiquitin, a eukaryotic tag for protein degradation, is linked to lysines in prokaryotic proteins destined for destruction, a process called pupylation. Abstract »  


Editorial Guides

Nancy R. Gough
18 November 2008: eg8.
With new modes of regulation, and new functions for members of the pathway, TGF-β breaks the canonical barrier. Abstract »   Full Text »   PDF »  



Loretta L. Hoover and Steven W. Kubalak
18 November 2008: pe48.
There are TGF-β–independent regulatory mechanisms and functions of Smads. Abstract »   Full Text »   PDF »  
Fang Liu
18 November 2008: pe49.
The distribution of promyelocytic leukemia protein between the nucleus and cytoplasm controls Smad activation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882