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Editors' Choice

Annalisa M. VanHook
25 November 2008: ec400.
Wnt signaling is required for early stages of blood-brain barrier formation in mice. Abstract »  
Wei Wong
25 November 2008: ec401.
Hypoxia inhibits the interaction of Wnt3a with a molecular chaperone, leading to improper processing of Wnt3a and proteosomal degradation. Abstract »  
Nancy R. Gough
25 November 2008: ec402.
The simplest eyes directly control ciliary beating to allow zooplankton larvae to swim toward the light. Abstract »  
Elizabeth M. Adler
25 November 2008: ec403.
Oleic acid in plasma inhibits neutrophil chemotaxis. Abstract »  
John F. Foley
25 November 2008: ec404.
Cooperation between Notch and Toll-like receptor signaling affects the expression of their target genes and can be blocked by interferon-{gamma}. Abstract »  
Paula A. Kiberstis
25 November 2008: ec405.
In obese mice, fat tissue stimulates proliferation of insulin-producing pancreatic cells via a neural relay through the liver, contributing to symptoms of metabolic syndrome. Abstract »  
Nancy R. Gough
25 November 2008: ec406.
Combining high-throughput immunofluorescence with microfluidics allows signaling dynamics to be quantified in single cells or across populations. Abstract »  
Wei Wong
25 November 2008: ec407.
Phosphorylation status of a cell cycle kinase signals whether kinetochores are properly attached to microtubules and determines whether mitosis can proceed. Abstract »  
Stella M. Hurtley
25 November 2008: ec408.
A reaction-diffusion model involving regulatory molecules and a microtubule-stabilizing phosphoprotein predicts the spatial distribution of microtubules during cell division. Abstract »  
Valda J. Vinson
25 November 2008: ec409.
The ligand binding pocket of the caffeine-binding human adenosine receptor has a position and orientation different from that of other G protein–linked receptors. Abstract »  
L. Bryan Ray
25 November 2008: ec410.
Characterization of receptor-like kinases in Arabidopsis links the ethylene synthetic pathway and regulation of cell wall biosynthesis. Abstract »  


Editorial Guides

Michael B. Yaffe
25 November 2008: eg9.
With the amount of data from screens increasing, researchers need better ways to make the information most useful. Abstract »   Full Text »   PDF »  



Petra May and Annalisa M. VanHook
25 November 2008: pc12.
Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Abstract »   Full Text »   Podcast »  


Research Articles

Pat P. Ongusaha, Hank H. Qi, Lakshmi Raj, Young-Bum Kim, Stuart A. Aaronson, Roger J. Davis, Yang Shi, James K. Liao, and Sam W. Lee
25 November 2008: ra14.
The Rho-associated kinase ROCK1 mediates the cellular response to UV radiation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kai Zurhove, Chikako Nakajima, Joachim Herz, Hans H. Bock, and Petra May
25 November 2008: ra15.
Cleavage of the intracellular domain of the lipoprotein receptor LRP1 allows it to transcriptionally inhibit inflammatory responses. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Leslayann C. Schecterson and Mark Bothwell
25 November 2008: pe50.
The p75 neurotrophin receptor functions as a co-receptor in three distinct systems that mediate repellant signals. Abstract »   Full Text »   PDF »  
Stephen M. King
25 November 2008: pe51.
Stimuli that alter the dimerization state of the dynein light chain DYNLL1 influence its regulatory functions. Abstract »   Full Text »   PDF »   Interactive Figure »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882