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Editors' Choice

John F. Foley
2 December 2008: ec411.
Intact eosinophil granules exhibit "intragranular" signaling in response to interferon-{gamma} and the chemokine CCL11 to mediate the secretion of granule proteins. Abstract »  
Elizabeth M. Adler
2 December 2008: ec412.
FGF and adenosine synergistically activate ERK, an interaction mediated through the physical association of their receptors. Abstract »  
Wei Wong
2 December 2008: ec413.
Activin treatment of pituitary cells increases its own production, as well as that of an opposing hormone. Abstract »  
L. Bryan Ray
2 December 2008: ec414.
In mice, a coactivator binds to a nuclear orphan receptor and regulates glucose-6-phosphatase transcription and thus glucose homeostasis. Abstract »  
Pamela J. Hines
2 December 2008: ec415.
The number of stem cells in plant roots is controlled by an auxin-cytokine feedback loop in which a particular gene integrates signals from both hormones. Abstract »  
Annalisa M. VanHook
2 December 2008: ec416.
The amino-terminal domain of Wnt antagonist Dickkopf-1 functions independently of the canonical Wnt signaling pathway. Abstract »  
L. Bryan Ray
2 December 2008: ec417.
The pleckstrin homology domain forms a molecular switch that regulates association of an adaptor protein with the cytoskeleton. Abstract »  

 

Podcasts

Sam W. Lee, Pat P. Ongusaha, and Annalisa M. VanHook
2 December 2008: pc13.
Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Abstract »   Full Text »   Podcast »  

 

Perspectives

H. Eric Xu and Yong Li
2 December 2008: pe52.
It is too soon to conclude that the physiological activities of PPAR{gamma} are truly ligand-independent. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882